ERCC2: Transporting and Regulating Proteins in The ER (G2068)

Target Name: ERCC2

NCBI ID: G2068

ERCC2

ERCC2: Transporting and Regulating Proteins in The ER

ERCC2 (endoplasmic reticulum-associated protein 2) is a protein that is expressed in most tissues of the body. It is a member of the family of transmembrane proteins, which means that it spans the cell membrane and reaches into the cytoplasm. ERCC2 is involved in various cellular processes, including the endoplasmic reticulum (ER), which is the system for the transport of proteins from the cytoplasm to the ER.

One of the functions of ERCC2 is to transport proteins into the ER. This is done through a process called endocytosis, which is the process by which a cell takes up external substances through its cell membrane. ERCC2 helps to facilitate this process by interacting with the protein transmembrane protease (TMP), which is responsible for cutting the protein chain and releasing it into the ER.

Another function of ERCC2 is to regulate the levels of protein synthesis in the ER. This is done through a process called protein quality control, which is the process by which the cell checks to ensure that the proteins it has produced are of the correct quality. ERCC2 is involved in this process by interacting with the protein kinase B- complex (BK-PLC), which is responsible for monitoring the levels of protein synthesis in the ER.

In addition to its role in transport and regulation, ERCC2 is also involved in the development and progression of various diseases, including cancer. This is done through its role in the regulation of cell growth, apoptosis (programmed cell death), and autophagy (the breakdown of cells by macrophages).

One of the most promising aspects of ERCC2 is its potential as a drug target. This is because of its involvement in various cellular processes that are involved in the development and progression of disease. For example, studies have shown that ERCC2 is involved in the regulation of cancer cell growth and has been shown to have anti-tumor effects.

In addition to its potential as a drug target, ERCC2 is also a potential biomarker for various diseases. This is done through its expression in various tissues and its ability to be used as a protein standard for various assays, including Western blotting.

Overall, ERCC2 is a protein that plays a critical role in various cellular processes in the body. Its involvement in the regulation of protein synthesis and cell growth makes it an attractive target for drug development, as well as a potential biomarker for various diseases. Further research is needed to fully understand the role of ERCC2 in these processes and its potential as a drug and biomarker.

Protein Name: ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit

Functions: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers

The "ERCC2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ERCC2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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