CPSF7: Key Regulator of Cell-Cell Adhesion and Cell Survival (G79869)

Target Name: CPSF7

NCBI ID: G79869

CPSF7

Other Name(s): CPSF 59 kDa subunit | cleavage and polyadenylation specific factor 7 | Cleavage and polyadenylation specificity factor subunit 7 (isoform 1) | Pre mRNA cleavage factor I, 59 kDa subunit | Cleavage and polyadenylation specific factor 7, transcript variant 1 | CFIm59 | pre-mRNA cleavage factor I, 59 kDa subunit | cleavage factor Im complex 59 kDa subunit | CPSF7 variant 1 | Pre-mRNA cleavage factor Im 59 kDa subunit | Cleavage factor Im complex 59 kDa subunit | cleavage and polyadenylation specificity factor 59 kDa subunit | pre-mRNA cleavage factor Im 59 kDa subunit | Pre-mRNA cleavage factor I, 59 kDa subunit | Cleavage and polyadenylation specificity factor subunit 7 | CPSF7_HUMAN | Cleavage and polyadenylation specificity factor 59 kDa subunit

CPSF7: Key Regulator of Cell-Cell Adhesion and Cell Survival

The CPSF7 protein is a member of the CPSF family, which plays a crucial role in the regulation of cell-cell adhesion. CPSF7 is a 59 kDa subunit and is expressed in various tissues, including brain, heart, and pancreas. It is known for its ability to interact with other CPSF proteins and for its role in the regulation of adhesion molecules in signal transduction pathways.

One of the key functions of CPSF7 is its ability to regulate the activity of adhesion molecules, such as cadherins and immunoglobulin adhesion fusion proteins (Ig-CAPP). These molecules are involved in the formation of tight junctions, which are a type of cell- cell adhesion that is essential for tissue repair and regeneration.

CPSF7 is also involved in the regulation of the production of cell surface antigens, such as cadherins and integrins. This is important for the development and maintenance of tissues and organs, as well as for the regulation of immune responses.

In addition to its role in cell-cell adhesion, CPSF7 is also involved in the regulation of cell survival and apoptosis. This is important for the regulation of cell division and for the development and maintenance of tissues and organs.

CPSF7 is also a potential drug target for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, studies have shown that CPSF7 is overexpressed in various types of cancer, including breast, ovarian, and prostate cancer. This suggests that targeting CPSF7 may be a promising strategy for the development of new treatments for these diseases.

CPSF7 is also a potential biomarker for several diseases, including cancer and neurodegenerative diseases. For example, studies have shown that CPSF7 is downregulated in the brains of individuals with Alzheimer's disease, a neurodegenerative disease. This suggests that targeting CPSF7 may be a promising strategy for the development of new treatments for this disease.

In conclusion, CPSF7 is a protein that plays a crucial role in the regulation of cell-cell adhesion and cell survival and apoptosis. Its functions are important for the development and maintenance of tissues and organs, as well as for the regulation of immune responses. CPSF7 is also a potential drug target and biomarker for several diseases, including cancer and neurodegenerative diseases. Further research is needed to fully understand the role of CPSF7 in these processes and to develop new treatments for these diseases.

Protein Name: Cleavage And Polyadenylation Specific Factor 7

Functions: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:8626397, PubMed:17024186, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:8626397, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:8626397, PubMed:17024186)

The "CPSF7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CPSF7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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