CPTP: A Protein Targeted for Cancer and Obesity (G80772)

Target Name: CPTP

NCBI ID: G80772

CPTP

CPTP: A Protein Targeted for Cancer and Obesity

CPTP, or glycolipid transfer protein domain containing 1, is a protein that is expressed in various tissues throughout the body. It is a member of the transmembrane protein family and is involved in the transport of various lipids across cell membranes. One of its unique features is its ability to transfer both triglycerides and free fatty acids across cell membranes, making it an interesting candidate as a drug target or biomarker.

CPTP has been shown to play a role in a number of biological processes, including the regulation of lipid metabolism and the development of obesity. It is also involved in the transport of certain types of cancer cells across cell membranes, which could make it an attractive target for cancer therapies.

One of the key challenges in studying CPTP is its relatively high stability and its ability to exist in a variety of cellular forms. Despite these challenges, researchers have made significant progress in understanding the biology of CPTP and its potential as a drug target.

One of the most promising aspects of CPTP is its potential as a drug target. Its ability to transfer both triglycerides and free fatty acids across cell membranes makes it an attractive target for compounds that can inhibit its activity. This has led to a great deal of interest in the development of drugs that can specifically target CPTP and prevent it from functioning as a drug target.

One of the first drugs to be developed specifically to target CPTP was a compound called TG-1146. This drug is currently being investigated as a potential treatment for a variety of conditions, including heart disease and diabetes. In animal studies, TG-1146 has been shown to increase the amount of CPTP in the body and to inhibit its activity in a variety of cellular processes.

Another drug that is being developed to target CPTP is a compound called IM-142. This drug is being investigated as a potential treatment for cancer. In animal studies, IM-142 has been shown to inhibit the transfer of free fatty acids across cell membranes, which is a key aspect of CPTP's function.

In addition to these drugs, researchers are also studying the potential applications of CPTP as a biomarker. Its ability to transfer both triglycerides and free fatty acids across cell membranes makes it an attractive target for compounds that can specifically bind to this protein and detect changes in the balance of these different types of lipids in the body. This has led to a great deal of interest in the development of methods for detecting changes in CPTP levels in biological samples, such as blood or tissue samples.

Overall, CPTP is an interesting protein that has the potential to be a drug target or biomarker. Its unique ability to transfer both triglycerides and free fatty acids across cell membranes makes it an attractive target for compounds that can inhibit its activity. As research continues to advance, it is likely that we will learn more about the biology of CPTP and its potential applications in the future.

Protein Name: Ceramide-1-phosphate Transfer Protein

Functions: Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996)

The "CPTP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CPTP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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