CREB3L3: Key Regulator of CREB-CBP Complex and TGF-β Signaling Pathways

Target Name: CREB3L3

NCBI ID: G84699

CREB3L3

CREB3L3: Key Regulator of CREB-CBP Complex and TGF-β Signaling Pathways

CREB3L3 (CR3L3_HUMAN), also known asCREB3-like protein 3, is a protein that is expressed in a variety of tissues throughout the body, including brain, heart, and muscle. It is a key regulator of the CREB-CBP complex, which is a critical transcription factor that is involved in a variety of cellular processes, including cell growth, differentiation, and stress response. In addition to its role in regulating gene expression, CREB3L3 has also been shown to play a role in cellular signaling pathways, including the TGF-β pathway.

CREB3L3 is a protein that is composed of 191 amino acid residues and has a calculated molecular weight of 21.9 kDa. It is expressed in a variety of tissues throughout the body, including the brain, heart, and muscle. It is a highly conserved protein, with similar sequences identified in a variety of species, including humans, mouse, and rat.

One of the key functions of CREB3L3 is its role as a regulator of the CREB-CBP complex. This complex is composed of the transcription factor CREB and the protein p100, and is responsible for promoting the transcription of target genes. CREB3L3 is a key component of this complex, and is essential for its function.

In addition to its role in regulating gene expression, CREB3L3 has also been shown to play a role in cellular signaling pathways. It is a potent inhibitor of the protein kinase TGF-β, which is involved in a variety of cellular processes, including cell growth, differentiation, and stress response. In addition, CREB3L3 has been shown to interact with the protein p53, which is a well-known tumor suppressor protein. This interaction between CREB3L3 and p53 suggests thatCREB3L3 may have a role in the regulation of cellular processes that are important for cancer development.

Another potential function of CREB3L3 is its role as a drug target. Because of its role in the regulation of cellular processes, as well as its conserved nature, CREB3L3 is a potential target for small molecules. Researchers have identified a number of small molecules that have been shown to interact with CREB3L3, and are currently in the process of testing these compounds as potential drug candidates.

In conclusion, CREB3L3 is a protein that is expressed in a variety of tissues throughout the body and is involved in the regulation of gene expression and cellular signaling pathways. Its role as a regulator of the CREB-CBP complex and its interaction with TGF-β and p53 suggest that it may be a potential drug target. Further research is needed to fully understand the functions of CREB3L3 and its potential as a drug.

Protein Name: CAMP Responsive Element Binding Protein 3 Like 3

Functions: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694)

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