Unlocking the Potential of COPS4 as a Drug Target and Biomarker

Target Name: COPS4

NCBI ID: G51138

COPS4

Unlocking the Potential of COPS4 as a Drug Target and Biomarker

Introduction

COP9 signalosome complex subunit 4 (COPS4) is a protein that plays a crucial role in the regulation of DNA double-strand break repair in eukaryotic cells. The COP9 signalosome is a protein complex that is formed when the repair machinery is activated and is responsible for ensuring that damaged DNA is accurately repaired and the cell is able to continue to divide and grow.

COPS4 is a key component of the COP9 signalosome and is responsible for the regulation of the complex's activity. It functions as a protein kinase, which means it uses the energy from ATP to add a phosphate group to a specific protein, allowing it to interact with other proteins and trigger a response.

Damaged DNA repair

Damaged DNA repair is a critical process that ensures that cells are able to recover from DNA damage and continue to function. When a DNA double-strand break occurs, the cell's repair machinery is activated to attempt to repair the damage. The COPS4 protein plays a crucial role in this process by regulating the activity of the repair machinery.

COPS4 is able to interact with the protein complex known as the nucleotide-remodeling complex (NRC), which is responsible for repairing damaged DNA. The NRC is composed of a variety of proteins, including cop90 and cop91, which work together to repair damaged DNA by using a specific set of tools to remove damaged bonds and add new ones.

COPS4 is also able to interact with the protein known as DNA-protein binding protein (DNBP), which is responsible for ensuring that the repair machinery is able to access the damaged DNA. DNBP is able to interact with the carbon-rich region of COPS4 , allowing it to influence the activity of the COPS4 protein.

COPS4 as a drug target

The ability of COPS4 to interact with the DNA repair machinery makes it an attractive drug target. By inhibiting the activity of COPS4, researchers are able to disrupt the repair machinery and prevent damaged DNA from being repaired. This can lead to the development of cancer cells that are more resistant to chemotherapy and other treatments.

In addition to its role in the DNA repair machinery, COPS4 is also a potential biomarker for cancer. The expression of COPS4 has been observed in a variety of cancer types, including breast, ovarian, and colorectal cancers. This suggests that COPS4 may be a useful biomarker for the diagnosis and treatment of these cancers.

COPS4 as a biomarker

The expression of COPS4 has also been observed in a variety of non-cancerous tissues and fluids, including blood, saliva, and urine. This suggests that COPS4 may be a useful biomarker for a variety of non-cancerous conditions. In addition, the levels of COPS4 have been shown to be elevated in the urine of people with certain types of cancer, which may indicate that it could be a useful diagnostic tool for these cancers.

COPS4 as a drug target

In addition to its potential as a biomarker, COPS4 is also an attractive drug target. The ability of COPS4 to interact with the DNA repair machinery makes it an attractive target for small molecules that are able to inhibit the activity of COPS4.

One class of small molecules that have been shown to be effective in inhibiting the activity of COPS4 is the benzimidazole class of drugs. These drugs are commonly used to treat hypertension and are able to inhibit the activity

Protein Name: COP9 Signalosome Subunit 4

Functions: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

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•   general information;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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