OR5M3: A Role in Sweet and Savory Perception and Olfactory Cell Development
OR5M3: A Role in Sweet and Savory Perception and Olfactory Cell Development
OR5M3 (Olfactory Receptor OR11-191) is a protein that is expressed in the olfactory epithelium, which is the lining of the nose. OR5M3 is a type of olfactory receptor, which is responsible for transmitting signals from the nose to the brain that indicate the presence of certain molecules in the air. In particular, OR5M3 is involved in the perception of sweet and savory substances.
OR5M3 is a transmembrane protein that is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain of OR5M3 is responsible for its ability to interact with other proteins, while the transmembrane domain is responsible for its ability to traverse the membrane and interact with other components of the cell. The intracellular domain is responsible for its ability to interact with the cell's cytoskeleton and other intracellular structures.
OR5M3 is a glycoprotein with a molecular weight of approximately 36 kDa. It consists of 214 amino acids, and it has a calculated pI of approximately 11.95. OR5M3 is expressed in the olfactory epithelium and is involved in the development and maintenance of the sense of smell.
One of the functions of OR5M3 is its role in the detection of sweet and savory substances. When a sweet or savory substance binds to OR5M3, it causes a conformational change that results in the formation of a more active conformation. This allows the olfactory receptor to transmit signals to the brain that the substance is present.
OR5M3 is also involved in the regulation of the growth and development of the olfactory epithelium. Studies have shown that OR5M3 plays a role in the development of new olfactory neurons, as well as the maintenance of the number of existing olfactory neurons. This is important for the proper functioning of the sense of smell.
In addition to its role in the detection and regulation of sweet and savory substances, OR5M3 is also thought to be involved in the development and maintenance of the immune system. Studies have shown that OR5M3 is involved in the regulation of the production of immune cells, as well as the response of these cells to potential threats.
OR5M3 is also a potential drug target in the treatment of various diseases. For example, it has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Additionally, OR5M3 has also been shown to be involved in the development of cancer, and may have potential as a therapeutic target for cancer treatment.
In conclusion, OR5M3 (Olfactory Receptor OR11-191) is a protein that is involved in the perception of sweet and savory substances, as well as the regulation of the growth and development of the olfactory epithelium. It is also thought to be involved in the development and maintenance of the immune system, and may be a potential drug target for the treatment of various diseases. Further research is needed to fully understand the role of OR5M3 in these processes, as well as its potential as a therapeutic target.
Protein Name: Olfactory Receptor Family 5 Subfamily M Member 3
Functions: Odorant receptor
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More Common Targets
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