TSPAN14: A Potential Drug Target and Biomarker for fabricated article

Target Name: TSPAN14

NCBI ID: G81619

TSPAN14

TSPAN14: A Potential Drug Target and Biomarker for fabricated article

Introduction

TSPAN14 (Tubulin sperm-associated protein 14) is a non-coding RNA molecule that is expressed in human tissues and plays a crucial role in the regulation of microtubule dynamics and stability. It is a key component of the microtubules, which are dynamic structures that organize and transport various cellular organelles during cell division, growth, and differentiation. TSPAN14 has been identified as a potential drug target and biomarker due to its unique structure, expression pattern, and function in various physiological processes.

Structure and Expression

TSPAN14 is a 21-kDa protein that consists of 195 amino acid residues. It has a unique feature, known as a \"T-loop,\" which is a conserved region that is found in the middle of the protein. The T- The loop is a platform for various post-translational modifications, such as tyrosination, acetylation, and polyglutamylation, which can modulate protein stability, localization, and interaction with other molecules.

TSPAN14 is expressed in various human tissues, including brain, heart, muscle, and organs, and has been shown to participate in various physiological processes, including cell division, migration, and invasion. It is also involved in the regulation of cell cycle progression, apoptosis, and autophagy. TSPAN14 has been shown to play a critical role in the regulation of mitosis, including the G1 phase, S phase, and G2 phase, as well as the metaphase and anaphase.

Drug Target Potential

TSPAN14 has been identified as a potential drug target due to its unique structure and function. The TSPAN14 protein is involved in the regulation of microtubule dynamics and stability, which are critical for the proper functioning of various cellular processes. This suggests that modulating TSPAN14 activity may have therapeutic benefits for various diseases.

One of the potential drug targets for TSPAN14 is the treatment of cancer. Cancer cells have altered microtubule dynamics that contribute to their rapid growth, invasiveness, and metastasis. TSPAN14 has been shown to play a critical role in regulating microtubule stability and dynamics, which may provide new insights into the mechanisms of cancer cell growth and metastasis.

In addition to cancer, TSPAN14 may also be a potential drug target for other diseases, such as neurodegenerative disorders and developmental disorders. TSPAN14 has been shown to participate in the regulation of neurotransmitter release, synaptic plasticity, and neuronal communication, which may be relevant to the pathophysiology of various neurodegenerative disorders.

Biomarker Potential

TSPAN14 has also been identified as a potential biomarker for various diseases. The regulation of microtubule dynamics and stability is involved in various physiological processes, including cell division, growth, and differentiation. This suggests that changes in microtubule dynamics and stability may be a potential biomarker for various diseases.

One of the potential applications of TSPAN14 as a biomarker is the diagnosis of neurodegenerative disorders. Neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by progressive neurodegeneration and loss of motor and cognitive function. TSPAN14 has been shown to play a critical role in the regulation of neurotransmitter release and neuronal communication, which may be relevant to the pathophysiology of these disorders.

In addition to neurodegenerative disorders, TSPAN14 may also be a potential biomarker for other diseases, such as cancer. The regulation of microtubule dynamics and stability is involved in

Protein Name: Tetraspanin 14

Functions: Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity)

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•   expression level;
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