BAP1: A Potential Drug Target for Apoptosis and Cell Cycle (G8314)

Target Name: BAP1

NCBI ID: G8314

BAP1

BAP1: A Potential Drug Target for Apoptosis and Cell Cycle

BAP1 (Bcl-2-associated protein 1) is a protein that is expressed in various tissues and cells throughout the body. It is a member of the Bcl family of proteins, which are known for their ability to interact with and modulate the activity of other proteins. One of the most significant functions of BAP1 is its role in the regulation of cell apoptosis, which is the process by which cells' natural life cycle is terminated when they have reached a certain level of dysfunction or when they have served their purpose.

BAP1 has been identified as a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for researchers to study, and its potential as a drug may have significant implications for the treatment of these diseases.

The BAP1 protein is composed of 214 amino acid residues and has a calculated molecular mass of 31.1 kDa. It is expressed in a variety of tissues, including the brain, spinal cord, heart, liver, and lymphoid organs. It is highly conserved, with There is only one blessed base substitution and two amino acid changes. BAP1 is a non-defoliating tumor gene expressed in a variety of tumors. Apoptosis-related genes such as p53 and Bcl-2 have high expression levels. Inhibiting the expression of BAP1 using RNAi technology can significantly inhibit tumor growth.

BAP1 is involved in the regulation of cell apoptosis, which is the process by which cells are naturally and irreversibly terminated when they have reached a certain level of dysfunction or when their useful function has been fulfilled. It plays a crucial role in the negative regulation of apoptosis, which is the process by which cells are naturally and irreversibly terminated when they have reached a certain level of dysfunction or when their useful function has been fulfilled. BAP1 is a positive regulator of apoptosis, which means that it promotes the process of apoptosis.

BAP1 is also involved in the regulation of cell cycle, the process by which cells grow and divide. It plays a role in the transition of cells from the G1 phase to the S phase of the cell cycle, which is the process by which cells prepare for cell division. BAP1 is also involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues.

BAP1 has been identified as a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for researchers to study, and its potential as a drug may have significant implications for the treatment of these diseases.

One of the most significant functions of BAP1 is its role in the regulation of cell apoptosis, which is the process by which cells are naturally and irreversibly terminated when they have reached a certain level of dysfunction or when their useful function has been fulfilled. BAP1 is a positive regulator of apoptosis, which means that it promotes the process of apoptosis.

Apoptosis is a natural and essential process for the survival and development of all living organisms. It is the process by which cells are naturally and irreversibly terminated when they have reached a certain level of dysfunction or when their useful function has been fulfilled. BAP1 plays a crucial role in the regulation of apoptosis, which is the process by which cells are naturally and irreversibly terminated when they have reached a certain level of dysfunction or when their useful function has been fulfilled.

BAP1 is a non-coding RNA, which means that it does not have a protein structure. It is expressed in a variety of tissues, including the brain, spinal cord, heart, liver, and lymphoid organs. It is highly conserved, with only One base substitution and two amino acid changes. BAP1 is a

Protein Name: BRCA1 Associated Protein 1

Functions: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor (PubMed:9528852)

The "BAP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BAP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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