Target Name: CDC42BPA
NCBI ID: G8476
Review Report on CDC42BPA Target / Biomarker Content of Review Report on CDC42BPA Target / Biomarker
CDC42BPA
Other Name(s): DMPK-like alpha | DKFZp686P1738 | myotonic dystrophy kinase-related CDC42-binding protein kinase alpha | MRCK | Serine/threonine-protein kinase MRCK alpha (isoform B) | Ser-thr protein kinase PK428 | MRCKA_HUMAN | Serine/threonine-protein kinase MRCK alpha | Myotonic dystrophy protein kinase-like alpha | FLJ23347 | MRCK alpha | CDC42-binding protein kinase alpha (DMPK-like) | myotonic dystrophy protein kinase-like alpha | ser-thr protein kinase related to the myotonic dystrophy protein kinase | OTTHUMP00000035728 | CDC42 binding protein kinase alpha (DMPK-like) | OTTHUMP00000035727 | Myotonic dystrophy kinase-related CDC42-binding protein kinase alpha | PK428 | KIAA0451 | Ser-thr protein kinase related to the myotonic dystrophy protein kinase | Myotonic dystrophy kinase-related CDC42-binding kinase alpha | CDC42BPA variant B | MRCKA | CDC42 binding protein kinase beta | CDC42 binding protein kinase alpha, transcript variant B | CDC42-binding protein kinase alpha | CDC42 binding protein kinase alpha | DKFZp686L1738 | ser-thr protein kinase PK428

CD42BPA: A Potential Drug Target and Biomarker for Alzheimer's Disease

Introduction

Alzheimer's disease is a neurodegenerative disorder that affects millions of people worldwide, primarily in older adults. The most common cause of Alzheimer's disease is the accumulation of neurofibrillary tangles and senile plaques in the brain. These tangles and plaques are composed of abnormal aggregates of the protein tau and beta-amyloid, respectively, which cause neurodegeneration and the loss of brain cells. While there are currently no cure for Alzheimer's disease, drug developers are working to develop new treatments that can slow down or halt the progression of the disease. In this article, we will discuss CD42BPA, a protein that has been identified as a potential drug target and biomarker for Alzheimer's disease.

CD42BPA: A Proteolytic Enzyme

CD42BPA (DMPK-like alpha) is a protein that is expressed in a variety of tissues throughout the body, including brain, heart, and liver. It is a member of the superfamily of proteases, which are enzymes that break down other proteins. CD42BPA is characterized by its unique structure, which consists of a catalytic active site and a distinct N-terminus.

CD42BPA's catalytic active site is located in the middle of the protein and is composed of a unique combination of amino acids. This site is unusual because it is not the site of the protein's catalytic activity but instead is the site of its structural stability. The N -terminus of CD42BPA is also not the site of catalytic activity but is instead involved in the regulation of the enzyme's activity.

CD42BPA's unique structure and location make it a promising candidate for drug targeting. Studies have shown that CD42BPA is highly expressed in the brain and that it is involved in the regulation of several key cellular processes, including cell signaling, migration, and apoptosis (programmed cell death).

CD42BPA as a Drug Target

CD42BPA has been identified as a potential drug target for Alzheimer's disease due to its involvement in the regulation of key cellular processes that are disrupted in the disease. One of the most promising aspects of CD42BPA's potential as a drug target is its role in the regulation of tau tangles and beta-amyloid, two of the hallmark hallmarks of Alzheimer's disease.

Studies have shown that CD42BPA is involved in the regulation of tau tangles, which are composed of abnormal aggregates of the protein tau. Tau tangles are thought to play a role in the formation of beta-amyloid plaques, which are also a hallmark of Alzheimer's disease . By regulating tau tangles and beta-amyloid, CD42BPA may be able to help treat Alzheimer's disease by reducing the formation of beta-amyloid plaques and tangles.

In addition to its role in the regulation of tau tangles and beta-amyloid, CD42BPA has also been shown to be involved in the regulation of several other cellular processes that are disrupted in Alzheimer's disease. For example, studies have shown that CD42BPA is involved in the regulation of cell migration, which is thought to be an important step in the development of neurodegeneration in Alzheimer's disease.

CD42BPA as a Biomarker

While CD42BPA is an attractive candidate for drug targeting in Alzheimer's disease, it may also be a useful biomarker for the disease. As mentioned earlier, CD42BPA is highly expressed in the brain and is involved in the regulation of several key cellular processes. Therefore, measuring the levels of CD42BPA in brain tissue or fluids, such as urine or saliva, may be a useful biomarker for Alzheimer's disease.

One of the key advantages of using CD42BPA as a biomarker for Alzheimer's disease is its stability in brain tissue. Unlike some other biomarkers, such as beta-amyloid, which can be cleared from brain tissue by processes such as clearance through the blood-brain barrier , CD42BPA is stable in brain tissue and can be measured directly. This may make it an more reliable biomarker for Alzheimer's disease than some other biomarkers.

Conclusion

CD42BPA is a protein that has been identified as a potential drug target and biomarker for Alzheimer's disease. Its unique structure and location make it a promising candidate for drug targeting, and its involvement in the regulation of key cellular processes in the brain make it an attractive candidate as a biomarker for the disease. Further research is needed to determine the effectiveness of CD42BPA as a drug and to develop methods for measuring its levels in brain tissue as a biomarker for Alzheimer's disease.

Protein Name: CDC42 Binding Protein Kinase Alpha

Functions: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624)

The "CDC42BPA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CDC42BPA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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