Discovering TAX1BP1: A Potential Drug Target for Various Diseases

Target Name: TAX1BP1

NCBI ID: G8887

TAX1BP1

Discovering TAX1BP1: A Potential Drug Target for Various Diseases

Tax1BP1 (TRAF6-binding protein) is a protein that is expressed in various tissues and cells throughout the body. It is a member of the B protein in the Traf6 signaling pathway, which plays a critical role in the regulation of cellular processes such as cell growth, differentiation, and inflammation.TAX1BP1 has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The TAX1BP1 protein is composed of 115 amino acid residues and has a calculated molecular mass of 13.9 kDa. It is expressed in a variety of tissues, including muscle, heart, liver, kidney, and brain. TAX1BP1 is predominantly localized to the cytoplasm of the cells, with a minor presence in the cell nucleus. It is a protein that can interact with the transcription factor TAX1BP1, which is responsible for regulating the expression of many cellular genes.

The TAX1BP1 protein is involved in several cellular processes that are crucial for normal cellular function. One of its functions is to regulate the activity of several enzymes that are involved in the metabolism of lipids and carbohydrates. These enzymes include enzymes that are involved in the synthesis of fatty acids, ketones, and nucleotides, as well as enzymes involved in the breakdown of carbohydrates. TAX1BP1 helps to ensure that the levels of these enzymes are regulated, which is essential for maintaining cellular energy homeostasis and metabolism.

Another function of TAX1BP1 is to regulate the expression of genes involved in cell adhesion and migration. These genes include adhesion molecules such as cadherins and integrins, as well as genes involved in regulation of cell migration. TAX1BP1 helps to ensure that these genes are turned on or off, depending on the cell's needs. This is important for the proper functioning of cells, as accurate cell-cell and cell-matrix interactions are critical for many cellular processes, including tissue repair and regeneration.

In addition to its functions in regulation of cellular processes, TAX1BP1 is also involved in the regulation of cellular signaling pathways. It has been shown to play a role in several signaling pathways, including the PI3K/Akt signaling pathway, the TGF-β signaling pathway , and the NF-kappa-B signaling pathway.TAX1BP1 has been shown to interact with several protein molecules, including the transcription factorTAX1BP1, the protein kinase PKC, and the transcription factorCREB. These interactions help to regulate the activity of these molecules and influence the cellular processes that are critical for normal cellular function.

The potential drug target status of TAX1BP1 is due to its involvement in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. TAX1BP1 has been shown to be involved in the regulation of cellular processes that are critical for the development and progression of these diseases. . For example, TAX1BP1 has been shown to be involved in the regulation of cell growth and differentiation, which are critical for the development of cancer. It has also been shown to play a role in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In addition, TAX1BP1 has been shown to be involved in the regulation of autoimmune disorders, including rheumatoid arthritis and multiple sclerosis.

The discovery of TAX1BP1 as a potential drug target and biomarker has implications for the development of new treatments for a variety of diseases. TAX1BP1 is a protein that plays a critical role in the regulation of cellular processes that are essential for normal cellular function. TAX1BP1 is involved in the regulation of cell growth, differentiation, metabolism, and signaling pathways, and has been shown to be involved in the development and progression of several diseases. Therefore, TAX1BP1 is a promising target for

Protein Name: Tax1 Binding Protein 1

Functions: Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:30459273, PubMed:29940186, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133)

The "TAX1BP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TAX1BP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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