TBC1D5: A Potential Drug Target and Biomarker (G9779)

Target Name: TBC1D5

NCBI ID: G9779

TBC1D5

TBC1D5: A Potential Drug Target and Biomarker

TBC1D5, also known as TBC1-domain member 5, is a gene that encodes a protein located in the TBC1 gene family. The TBC1 gene family is a group of non-coding RNA-protein interactions that have been implicated in various cellular processes, including cell signaling, DNA replication, and repair. TBC1D5 is one of the proteins encoded by the TBC1 gene.

The TBC1D5 protein is a 21-kDa protein that is expressed in various tissues and cells. It is highly conserved, with a calculated pI of 6.5 and a predicted localization in the cytoplasm. TBC1D5 is involved in various cellular processes, including cell signaling, DNA replication, and repair.

One of the key functions of TBC1D5 is its role in the regulation of DNA replication. TBC1D5 has been shown to play a crucial role in the regulation of DNA replication initiation, as well as the regulation of DNA replication efficiency. TBC1D5 has been shown to interact with the DNA replication complex, where it is involved in the recruitment of the complex to the site of DNA replication.

Another function of TBC1D5 is its role in cell signaling. TBC1D5 has been shown to play a role in the regulation of cell signaling pathways, including the T cell signaling pathway. TBC1D5 has been shown to interact with the protein PD-L1, which is a negative regulator of the T cell signaling pathway. This interaction between TBC1D5 and PD-L1 suggests that TBC1D5 may be a potential drug target for cancer treatment.

In addition to its role in cell signaling, TBC1D5 has also been shown to be involved in the regulation of DNA repair. TBC1D5 has been shown to play a role in the regulation of DNA repair pathways, including the DNA double-strand break repair pathway. TBC1D5 has been shown to interact with the protein DNA-binding protein BRCA1, which is involved in the regulation of DNA repair. This interaction between TBC1D5 and DNA-binding protein BRCA1 suggests that TBC1D5 may be a potential biomarker for the diagnosis and prognosis of certain types of cancer.

TBC1D5 has also been shown to play a role in the regulation of cell adhesion. TBC1D5 has been shown to interact with the protein cadherin, which is involved in cell adhesion. This interaction between TBC1D5 and cadherin suggests that TBC1D5 may be a potential drug target for the treatment of cell adhesion-related diseases.

In conclusion, TBC1D5 is a gene that encodes a protein that is involved in various cellular processes, including cell signaling, DNA replication, and repair, as well as cell adhesion. The TBC1D5 protein is highly conserved and has been shown to play a crucial role in the regulation of DNA replication initiation, cell signaling, DNA repair, and cell adhesion. These properties make TBC1D5 a potential drug target for cancer treatment. Further research is needed to fully understand the role of TBC1D5 in cellular processes and its potential as a drug target.

Protein Name: TBC1 Domain Family Member 5

Functions: May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492)

The "TBC1D5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TBC1D5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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