TNFSF18: A Potential Drug Target for Multiple Diseases (G8995)

Target Name: TNFSF18

NCBI ID: G8995

TNFSF18

TNFSF18: A Potential Drug Target for Multiple Diseases

Tumor necrosis factor superfamily member 18 (TNFSF18) is a protein that plays a crucial role in cell signaling and immune responses. It is a cytoplasmic protein that is expressed in a variety of tissues, including the brain, heart, liver, and muscle. TNFSF18 has been identified as a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The TNFSF18 protein is composed of 18 constant and 1 variable region proteins that are expressed in different tissues. The constant region proteins are responsible for the protein's structural stability, while the variable region contains the protein's unique functions and interactions. The variable region of TNFSF18 contains a variety of different functions, including the ability to interact with other proteins and extracellular signaling molecules.

One of the most significant functions of TNFSF18 is its role in the immune response. TNFSF18 is a key member of the TNF-alpha signaling pathway, which is involved in the regulation of immune responses and inflammation. In this pathway, TNFSF18 plays a critical role in the regulation of T cell proliferation and differentiation, as well as the regulation of immune cell function.

In addition to its role in immune regulation, TNFSF18 is also involved in the regulation of cell signaling and metabolism. For example, TNFSF18 has been shown to play a role in the regulation of cell growth and apoptosis, as well as the regulation of cell metabolism and energy production.

The potential drug target and biomarker properties of TNFSF18 are due to its unique structure and function. Because of its involvement in multiple cellular processes, TNFSF18 is a promising target for the development of new drugs for a variety of diseases. For example, because TNFSF18 is involved in the regulation of immune responses, potential drugs that target TNFSF18 could be effective in treating a variety of autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. In addition, TNFSF18 is also involved in the regulation of cell signaling and metabolism, which makes it a potential target for the treatment of a variety of metabolic disorders, including diabetes.

Another potential application of TNFSF18 as a drug target is its role in cancer. TNFSF18 has been shown to play a role in the regulation of cancer cell growth and survival, as well as the regulation of cell signaling and metastasis. As a result, potential drugs that target TNFSF18 could be effective in treating a variety of cancers, including breast, lung, and ovarian cancers.

In conclusion, TNFSF18 is a protein that plays a critical role in cell signaling and immune responses. Its unique structure and function make it a promising target for the development of new drugs for a variety of diseases. As more research is conducted on the biology and pharmacology of TNFSF18, it is likely that new treatments will be discovered that will improve the health and quality of life for many individuals.

Protein Name: TNF Superfamily Member 18

Functions: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity)

The "TNFSF18 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TNFSF18 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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