TNS2: A novel drug target and biomarker for neurodegenerative diseases

Target Name: TNS2

NCBI ID: G23371

TNS2

TNS2: A novel drug target and biomarker for neurodegenerative diseases

Introduction

Tensin-like C1 domain-containing phosphatase (TNS2) is a protein that plays a crucial role in cellular signaling and metabolism. TNS2 is a member of the cAMP-dependent protein kinase (PDE1) family and is expressed in various tissues, including neurons, muscle cells, and red blood cells. TNS2 functions as a negative regulator of the protein kinase A (PKA), which is known to play a pivotal role in neurotransmitter signaling, inflammation, and cell survival.

The identification of TNS2 as a potential drug target and biomarker for neurodegenerative diseases has gained significant interest in recent years. Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the progressive loss of brain cells and the accumulation of neurofibrillary tangles and other pathological hallmarks. These conditions are associated with significant morbidity and mortality, making them a major public health burden.

TNS2 as a drug target

TNS2 has been identified as a potential drug target due to its unique structure and its involvement in cellular signaling pathways. TNS2 is a type I transmembrane protein that contains a C1 domain, which is responsible for its catalytic activity. The C1 domain is involved in the regulation of protein-protein interactions and is known to play a role in the regulation of intracellular signaling pathways.

TNS2 has been shown to play a negative role in the regulation of the PKA pathway, which is involved in the production of intracellular signaling molecules, including cAMP. ThePKA pathway is a critical pathway involved in the regulation of various cellular processes, including neurotransmitter signaling, inflammation, and cell survival. The deregulation of the PKA pathway has been implicated in the development and progression of neurodegenerative diseases.

TNS2 has been shown to regulate the PKA pathway by inhibiting the activity of the protein kinase A, which is the catalytic subunit of the PKA enzyme. This inhibition of PKA activity by TNS2 has been shown to play a role in the regulation of cellular processes such as cell survival, proliferation, and migration.

TNS2 as a biomarker

TNS2 has also been identified as a potential biomarker for neurodegenerative diseases. The accumulation of neurofibrillary tangles and other pathological hallmarks in neurodegenerative diseases is associated with the progressive loss of brain cells and the dysfunction of neural circuits. TNS2 has been shown to be involved in the regulation of the PKA pathway, which is involved in the production of intracellular signaling molecules that are critical for the maintenance of cellular homeostasis.

The dysfunction of the PKA pathway has been implicated in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. TNS2 has been shown to play a negative role in the regulation of the PKA pathway, which has implications for the development and progression of these conditions.

In addition to its potential clinical implications, the identification of TNS2 as a biomarker for neurodegenerative diseases has significant implications for the development of new diagnostic tools. The development of biomarkers for neurodegenerative diseases has the potential to improve the accuracy and speed of disease diagnosis, as well as the development of new therapeutic approaches.

Conclusion

TNS2 is a protein that has significant implications for the development and progression of neurodegenerative diseases. Its unique structure and involvement in cellular signaling pathways make it an attractive drug target and biomarker for neurodegenerative diseases. Further research is needed to fully understand the role of TNS2 in neurodegenerative diseases and its potential as a therapeutic approach.

Protein Name: Tensin 2

Functions: Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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