TOMM70: A Protein Involved in Cellular Processes and Disease (G9868)

Target Name: TOMM70

NCBI ID: G9868

TOMM70

TOMM70: A Protein Involved in Cellular Processes and Disease

TOMM70 (TOM70_HUMAN), also known as TOMM70, is a protein that is expressed in various tissues of the human body. It is a member of the TOMM family, which includes TOMM40, TOMM55, TOMM65, TOMM71, and TOMM73. The TOMM family is characterized by the presence of a unique N-terminal domain called TOMM, which is responsible for the protein's stability and stability-dependent interactions.

TOMM70 is a 70 kDa protein that is expressed in the brain, heart, liver, and kidneys. It is primarily localized to the endoplasmic reticulum (ER) and endosomal system (ES), which are responsible for the delivery of proteins to various cell types. TOMM70 is also expressed in various tissues of the body, including the placenta, spleen, and skeletal muscles.

One of the unique features of TOMM70 is its ability to interact with other proteins, particularly those that are involved in the delivery and stability of intracellular proteins. This interaction with other proteins makes TOMM70 an attractive drug target and potential biomarker for various diseases.

In addition to its role in protein delivery, TOMM70 is also involved in the regulation of cellular processes that are critical for cell survival. For example, TOMM70 has been shown to play a role in the regulation of mitochondrial function, which is critical for the production of energy by the cell.

TOMM70 has also been shown to interact with various signaling pathways that are involved in cellular processes that are important for cell growth, angiogenesis, and inflammation. For example, TOMM70 has been shown to interact with the TGF-β pathway, which is involved in the regulation of cell growth and differentiation.

In addition to its role in cellular processes, TOMM70 is also involved in the regulation of the immune system. For example, TOMM70 has been shown to interact with the PDGF receptor, which is involved in the regulation of cellular growth and differentiation, including the development and function of immune cells.

TOMM70 has also been shown to be involved in the regulation of the blood-brain barrier (BBB), which is responsible for the regulation of the movement of molecules into and out of the brain. The BBB is a critical barrier that helps to protect the brain from harmful substances, but it is also involved in the regulation of the delivery of beneficial molecules.

In conclusion, TOMM70 is a protein that is expressed in various tissues of the human body and is involved in the regulation of cellular processes that are critical for cell survival. Its ability to interact with other proteins and signaling pathways makes it an attractive drug target and potential biomarker for various diseases. Further research is needed to fully understand the role of TOMM70 in cellular processes and its potential as a drug target.

Protein Name: Translocase Of Outer Mitochondrial Membrane 70

Functions: Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812)

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•   general information;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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