Tumor Protein p73: A Promising Drug Target and Biomarker (G7161)

Target Name: TP73

NCBI ID: G7161

TP73

Tumor Protein p73: A Promising Drug Target and Biomarker

Tumor protein p73 (TP73) is a transmembrane protein that is expressed in various tissues, including the brain, pancreas, and gastrointestinal tract. It plays a crucial role in cell signaling, DNA repair, and apoptosis, which are processes that are often disrupted in cancer cells. TP73 has also been implicated in the development and progression of various diseases, including cancer. As a result, targeting TP73 has become an attractive strategy for the development of new treatments for cancer and other diseases.

Drugs that target TP73 have the potential to inhibit its functions, leading to the inhibition of cancer cell growth, apoptosis, and metastasis. Moreover, these drugs may also have beneficial effects on normal cells, leading to reduced side effects. TP73 has also been implicated in the development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Therefore, targeting TP73 may also have implications for the treatment of these debilitating diseases.

Expression and Localization of TP73

TP73 is a 21-kDa transmembrane protein that is expressed in various tissues, including the brain, pancreas, and gastrointestinal tract. It is highly expressed in the brain, with low levels expressed in other tissues. TP73 is predominantly expressed in the peri-glial cells of the appendix, and it is also expressed in the glial cells of the brain.

TP73 localizes to the peri-glial cells of the appendix, which are the cells that line the intestinal tract and are responsible for absorbing nutrients from the food. In the brain, TP73 is primarily expressed in the astrocytes, which are a type of glial cell that support and protect nerve cells. It is also expressed in the microglia, which are the immune cells of the brain.

Function of TP73

TP73 is involved in various cellular processes that are important for cell survival and growth. It plays a crucial role in cell signaling, DNA repair, and apoptosis.

1. Cell Signaling

TP73 is involved in cell signaling by regulating the activities of various signaling pathways. It has been shown to play a role in the Wnt signaling pathway, which is a critical pathway involved in the development and maintenance of tissues. TP73 has been shown to regulate the activity of the Wnt signaling pathway by regulating the activity of the Wnt receptor, which is a transmembrane protein that is expressed in various tissues, including the brain.

2. DNA Repair

TP73 is involved in DNA repair by regulating the activities of various DNA repair pathways. It has been shown to play a role in the DNA double-strand break repair pathway, which is a critical pathway for repairing DNA damage that can result from exposure to radiation or other stressors. TP73 has been shown to regulate the activity of this pathway by regulating the activity of the DNA damage-associated protein 5 (DNAPK), which is involved in the repair of DNA double-strand breaks.

3. Apoptosis

TP73 is involved in apoptosis by regulating the activities of various apoptosis-associated proteins. It has been shown to play a role in the Bcl-2 protein, which is a critical protein involved in the regulation of apoptosis. TP73 has been shown to regulate the activity of this protein by regulating its activity through the interaction with

Protein Name: Tumor Protein P73

Functions: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761)

The "TP73 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TP73 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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