TP53RK: A Potent Drug Target and Potential Biomarker for Atypical Serine/Threonine Protein Kinase-Mediated Diseases

Target Name: TP53RK

NCBI ID: G112858

TP53RK

TP53RK: A Potent Drug Target and Potential Biomarker for Atypical Serine/Threonine Protein Kinase-Mediated Diseases

Atypical serine/threonine protein kinase (ASPK) kinases are a family of non-poisonous kinases that play crucial roles in various cellular processes. These kinases are involved in cell signaling pathways, including DNA damage repair, cell adhesion, and cell survival. TP53RK, a member of the ASPK family, is a unique protein that has been identified as a potential drug target and biomarker for several diseases.

TheTP53RK: Structure and Function

The TP53RK protein is a 21 kDa protein that is expressed in various cell types, including human tissues and organs. It is a key regulator of the DNA damage response pathway, which is critical for maintaining cellular health and preventing diseases such as cancer and neurodegenerative disorders.

The TP53RK protein consists of a 21 kDa catalytic active site, a 165 amino acid tail, and a 156 amino acid N-terminus. The catalytic active site is the site of the protein's catalytic activity, which is responsible for the chemical reaction that enables the protein to catalyze the conversion of serine to threonine.

TP53RK has been shown to play a crucial role in the DNA damage repair pathway. When DNA double-strand breaks occur, the TP53RK protein is recruited to the site of the break and helps to repair the damage. This protein has been shown to enhance the efficiency of DNA repair in various cell types, including cancer cells.

In addition to its role in the DNA damage repair pathway, TP53RK has also been shown to play a critical role in cell adhesion and survival. This protein has been shown to be involved in the regulation of cell adhesion, as well as the association with various signaling pathways that are involved in cell survival.

Drug Target Potential

The TP53RK protein has been identified as a potential drug target due to its involvement in the DNA damage repair pathway and its ability to enhance the efficiency of DNA repair in various cell types. Several studies have shown that inhibiting the TP53RK protein can enhance the sensitivity of cancer cells to chemotherapy and radiation therapy.

In addition to its potential as a drug target, TP53RK has also been identified as a potential biomarker for several diseases. The TP53RK gene has been shown to be involved in the regulation of various cellular processes, including the DNA damage response pathway. This protein has been shown to be expressed in various tissues and organs, including brain, heart, and muscle.

Combining ItsDrug Target and Biomarker Properties

The TP53RK protein has the potential to be a drug target and biomarker for several diseases. Its involvement in the DNA damage repair pathway makes it an attractive target for cancer therapies that target this pathway. Additionally, TP53RK's role in cell adhesion and survival makes it an attractive target for therapies that aim to enhance cellular signaling pathways.

Conclusion

In conclusion, TP53RK is a unique protein that has been identified as a potential drug target and biomarker for several diseases. Its involvement in the DNA damage repair pathway makes it an attractive target for cancer therapies, while its role in cell adhesion and survival makes it an attractive target for therapies that aim to enhance cellular signaling pathways. Further research is needed to fully understand the role of TP53RK in disease and to develop effective therapies that target this protein.

Protein Name: TP53 Regulating Kinase

Functions: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806)

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