TP53INP1: A Promising Drug Target and Biomarker for p53-Inducible p53DINP1

Target Name: TP53INP1

NCBI ID: G94241

TP53INP1

TP53INP1: A Promising Drug Target and Biomarker for p53-Inducible p53DINP1

p53 is one of the most widely studied gene pathways in the human genome. The p53 gene is a tumor suppressor gene that plays a crucial role in regulating various cellular processes, including DNA repair, cell growth, and apoptosis. p53 gene mutations have been implicated in numerous diseases, including cancer, neurodegenerative disorders, and aging. Therefore, identifying and targeting p53-mediated pathways is a promising strategy to develop new treatments.

TP53INP1, a synthetic analog of the natural protein p53, is a potential drug target and biomarker for p53-mediated diseases. In this article, we will discuss the biology of TP53INP1, its potential as a drug target, and its potential as a biomarker for p53-mediated diseases.

The p53-Inducible p53DINP1 Molecule

TP53INP1 is a synthetic analog of the natural protein p53 that consists of 21 amino acid residues. It has a distinct N-terminus, a catalytic center, and a C-terminus that is similar to the natural p53 protein. The C-terminus of TP53INP1 contains a putative N-endopeptide loop that can bind to specific DNA targets, including p53-mediated pathways.

The p53 pathway is a complex network that involves various proteins, including p53, p63, and p78. These proteins work together to regulate various cellular processes, including DNA repair, cell growth, and apoptosis. TP53INP1 has been shown to interact with p53 and p63, suggesting that it may have p53-mediated functions.

Inducible p53DINP1 Mutation

Mutations in the p53 gene have been implicated in numerous diseases, including cancer, neurodegenerative disorders, and aging. The p53-Inducible p53DINP1 mutation is a unique mutation that has been identified in TP53INP1. This mutation allows TP53INP1 to induce p53-mediated responses, including DNA damage repair and cell proliferation.

The p53-Inducible p53DINP1 mutation has been shown to promote various cellular processes, including the growth and survival of cancer cells, the development of neurodegenerative disorders, and the aging process. This mutation has also been linked to various diseases, including cancer, neurodegenerative disorders, and aging. Therefore, targeting this mutation may be a promising strategy to develop new treatments for these diseases.

Targeting TP53INP1 for Cancer and Neurodegenerative Disorders

Targeting TP53INP1 may be a promising strategy to develop new treatments for cancer and neurodegenerative disorders. TP53INP1 has been shown to promote the growth and survival of cancer cells, including melanoma, breast cancer, and colon cancer.

In a preclinical study, TP53INP1 was shown to inhibit the growth and promote the apoptosis of cancer cells. This suggests that targeting TP53INP1 may be a promising strategy to develop new treatments for cancer.

In addition to its potential as a cancer treatment, TP53INP1 may also be a promising biomarker for neurodegenerative disorders. The p53 pathway is involved in various cellular processes that are important for brain function, including neurotransmitter synthesis and synaptic plasticity. Therefore, TP53INP1 may be involved in the development and progression of neurodegenerative disorders.

Targeting TP53INP1 for Neurodegenerative Disorders

Targeting TP53INP1

Protein Name: Tumor Protein P53 Inducible Nuclear Protein 1

Functions: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC

The "TP53INP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TP53INP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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