LSINCT5: A Potential Drug Target and Biomarker (G101234261)

Target Name: LSINCT5

NCBI ID: G101234261

LSINCT5

Other Name(s): long stress-induced non-coding transcript 5 | Long stress-induced non-coding transcript 5

LSINCT5: A Potential Drug Target and Biomarker

LSINCT5 is a gene that encodes a protein known as long short-chain neurotrophic factor (LSNF), which is involved in the development and maintenance of neural circuits in the brain. The neurotrophic factor family of proteins is known for their ability to promote the survival and proliferation of neural cells, and LSNF is no exception. This protein has been shown to play a crucial role in the development of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and chronic pain.

The Importance of LSINCT5

The identification of potential drug targets and biomarkers is a crucial step in the development of new treatments for neurological disorders. LSINCT5 is a promising drug target due to its involvement in the development and maintenance of neural circuits, as well as its potential to modulate pain perception.

Properties of LSINCT5

LSINCT5 is a 14kDa protein that is expressed in a variety of tissues, including brain, heart, and skeletal muscles. It is highly soluble in water and has a calculated pI of 5.8. LSINCT5 is associated with the neurotrophic factor family and is characterized by a variety of post-translational modifications, including phosphorylation and ubiquitination.

LSINCT5 functions as a neurotrophic factor by promoting the survival and proliferation of neural cells. It does this by interacting with its cognate receptor, TrkB, which is a G protein-coupled receptor that is involved in the regulation of neural circuits. TrkB is a potent agonist for LSINCT5 and has been shown to promote the survival of rat neural stem/progenitor cells (NSPCs) and to increase the migration of these cells to the developing brain.

In addition to its neurotrophic functions, LSINCT5 has also been shown to play a role in pain perception. It is involved in the modulation of pain sensitivity and has been shown to play a negative role in the development of chronic pain. Specifically, LSINCT5 has been shown to reduce the hypersensitivity to pain in rats and to increase the pain tolerance in mice.

LSINCT5 as a potential drug target

The identification of LSINCT5 as a potential drug target is based on its involvement in the development and maintenance of neural circuits and its potential to modulate pain perception. Several studies have shown that modulating LSINCT5 activity could be a useful strategy for the development of new treatments for neurological disorders.

One potential approach to modulating LSINCT5 activity is to target its phosphorylation. Phosphorylation of LSINCT5 has been shown to play a role in its neurotrophic functions and is a target for several drugs used to treat neurological disorders. For example, inhibitors of the phosphatidylinositol (PI) signaling pathway, which is involved in LSINCT5 phosphorylation, have been shown to be effective in treating Alzheimer's disease and other neurological disorders.

Another potential approach to modulating LSINCT5 activity is to target its ubiquitination. Ubiquitination is a post-translational modification that involves the attachment of a ubiquitin tag to a protein. LSINCT5 is involved in ubiquitination and has been shown to play a role in the regulation of neural circuits. Therefore, drugs that can inhibit ubiquitination of LSINCT5 may be a useful strategy for treating neurological disorders.

LSINCT5 as a biomarker

LSINCT5 has also been shown to be a potential biomarker for the development of neurological disorders. The loss of LSINCT5 has been observed in a variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, and chronic pain. Therefore, LSINCT5 may be a useful biomarker for the diagnosis and prognosis of these disorders.

Conclusion

LSINCT5 is a protein that is involved in the development and maintenance of neural circuits and has been shown to play a role in the modulation of pain perception. Its involvement in these functions makes it a promising drug target and a potential biomarker for the development of neurological disorders. Further research is needed to fully understand the role of LSINCT5

Protein Name: Long Stress-induced Non-coding Transcript 5

The "LSINCT5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LSINCT5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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