LOC105375237: A Protein Model for Neurodegenerative Diseases (G105375237)
LOC105375237: A Protein Model for Neurodegenerative Diseases
LOC105375237 (LOC105375237 variant X1) is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and pancreas. It is a member of the Tetraspanin family, which are a group of transmembrane proteins that play a variety of roles in cellular signaling and organization.
LOC105375237 variant X1 is characterized by a single amino acid difference between its normal and mutated forms. In the normal form, the protein has 29 amino acids, while in the mutated form, it has a single amino acid substitution at position 28, resulting in a change from Asp to Asn. This single amino acid substitution has a significant impact on the structure and function of the protein.
The mutated form of LOC105375237 has been shown to have altered protein stability and localization in the brain, which could potentially make it a drug target or biomarker. Studies have shown that the mutated protein is more likely to be present in the endoplasmic reticulum (ER), which is the protein synthesis and quality control facility in the brain. This is consistent with the idea that the mutated protein is not functioning correctly, leading to its accumulation in the brain and potentially contributing to the development of neurodegenerative diseases.
In addition to its potential role as a drug target or biomarker, LOC105375237 may also be a valuable tool for the study of neurodegenerative diseases. The accumulation of misfolded proteins, such as LOC105375237 mutated, in the brain is a hallmark of neurodegenerative diseases, and could be used as a diagnostic or therapeutic target.
Furthermore, LOC105375237 variant X1 may also be used as a model for studying protein-protein interactions and other cellular signaling pathways. The protein's unique structure and function as a Tetraspanin suggest that it plays an important role in the organization and regulation of cellular signaling pathways.
In conclusion, LOC105375237 (LOC105375237 variant X1) is a protein that is expressed in various tissues of the body and is characterized by a single amino acid substitution that has altered its structure and function. The mutated form of LOC105375237 has been shown to have altered protein stability and localization in the brain, which could make it a potential drug target or biomarker for neurodegenerative diseases. Furthermore, LOC105375237 variant X1 may also be a valuable tool for the study of protein-protein interactions and other cellular signaling pathways.
Protein Name: Uncharacterized LOC105375237
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• general information;
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• expression level;
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More Common Targets
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