Regulation of Muscle Contractions By BTN3A1 (G11119)

Target Name: BTN3A1

NCBI ID: G11119

BTN3A1

Regulation of Muscle Contractions By BTN3A1

BTN3A1, also known as Butyrophilin subfamily 3 member A1, is a protein that is expressed in various tissues throughout the body. It is a key regulator of muscle contractions and has been identified as a potential drug target in the field of muscle physiology.

The BTN3A1 protein is composed of 120 amino acid residues and has a calculated molecular weight of 13.9 kDa. It is localized to the endoplasmic reticulum (ER) and is predominantly expressed in muscle tissues, including skeletal muscles, heart muscle, and smooth muscles. It is also expressed in various other tissues, including the liver, kidney, and central nervous system (CNS).

BTN3A1 is a member of the Butyrophilin subfamily 3, which is a family of proteins that are characterized by their ability to regulate muscle contractions. The BTN3A1 protein is similar to other members of this subfamily, such as Myosin and Myosin light chain, in that it contains a unique N-terminal region that is involved in the regulation of muscle contraction.

One of the key functions of BTN3A1 is its ability to regulate the activity of the myosin ATPase, which is a protein that is involved in the production of ATP, the energy currency of the cell. Myosin ATPase is a key regulator of muscle contractions and is activated by the release of ATP from the sarcolemma, the outer membrane of the muscle cell.

In addition to its role in muscle contractions, BTN3A1 is also involved in the regulation of various cellular processes that are important for maintaining muscle function. For example, it is has been shown to play a role in the regulation of muscle stem cell proliferation and differentiation, as well as in the regulation of muscle fiber size and arrangement.

BTN3A1 has also been identified as a potential drug target in the field of muscle physiology. Studies have shown that BTN3A1 is highly expressed in muscle tissues and that its levels are often reduced in muscle-injured individuals. Additionally, several drugs that have been shown to modulate myosin ATPase activity, such as aminoglycoside drugs, have been shown to also modify BTN3A1 levels in muscle tissues.

In conclusion, BTN3A1 is a key regulator of muscle contractions and has been identified as a potential drug target in the field of muscle physiology. Further research is needed to fully understand the role of BTN3A1 in muscle function and to develop effective therapies for muscle injuries and disease.

Protein Name: Butyrophilin Subfamily 3 Member A1

Functions: Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate

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