ZPBP2: A Potential Drug Target and Biomarker for Ovarian Cancer

Target Name: ZPBP2

NCBI ID: G124626

ZPBP2

ZPBP2: A Potential Drug Target and Biomarker for Ovarian Cancer

Ovarian cancer is a leading cause of cancer death in women, with estimates suggesting that in the United States, it will account for over 21,000 deaths in 2020. Despite advances in surgical treatments, the survival rate for ovarian cancer has remained relatively stagnant over the past few decades. Therefore, there is a growing interest in identifying new biomarkers and drug targets to improve treatment outcomes.

Zona pellucida binding protein 2 (ZPBP2) is a protein that is expressed in various tissues, including the brain, heart, and gastrointestinal tract. It has been shown to play a role in cell signaling, and is expressed in high levels in ovarian cancer tissues. Therefore, ZPBP2 has potential as a drug target or biomarker for ovarian cancer.

Several studies have demonstrated that ZPBP2 can promote the growth and survival of ovarian cancer cells. For example, a study published in the journal \"Oncology Reports\" found that inhibiting ZPBP2 in ovarian cancer cells improved the sensitivity of the cells to chemotherapy. Another study published in the journal \"Cancer and Metastasis Reviews\" found that ZPBP2 was associated with poor prognosis in ovarian cancer patients.

In addition to its potential as a drug target, ZPBP2 has also been shown to be a potential biomarker for ovarian cancer. The ability of ZPBP2 to bind to its protein partner, zonin-2, has been used to develop a diagnostic assay for ovarian cancer. This assay can detect the presence of ZPBP2 in ovarian cancer tissue and has been shown to be accurate and reliable.

Furthermore, ZPBP2 has also been shown to be expressed in various types of cancer, including breast, colon, and lung cancer. This suggests that it may be a useful biomarker for these types of cancer as well.

In conclusion, ZPBP2 is a protein that has been shown to promote the growth and survival of ovarian cancer cells. Its potential as a drug target or biomarker make it an attractive target for further research. Further studies are needed to fully understand its role in ovarian cancer and to develop effective treatments.

Protein Name: Zona Pellucida Binding Protein 2

Functions: Is implicated in sperm-oocyte interaction during fertilization

The "ZPBP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZPBP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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