RAET1L: A GPCR Molecule Implicated in Multiple Diseases (G154064)

Target Name: RAET1L

NCBI ID: G154064

RAET1L

RAET1L: A GPCR Molecule Implicated in Multiple Diseases

RAET1L (Remorfinyl leukotriene receptor 1-like) is a protein that is expressed in various tissues throughout the body, including the lungs, heart, kidneys, and eyes. It is a G protein-coupled receptor (GPCR), which means it is a transmembrane protein that spans the cell membrane and is involved in signaling inside and outside the cell.

The RAET1L gene was identified in the late 1990s as a potential drug target for various diseases, including asthma, allergies, and chronic obstructive pulmonary disease (COPD). The gene has since been shown to be involved in the regulation of cellular processes that are important for maintaining the health and function of the respiratory system, including inflammation, fibrosis, and airway remodeling.

One of the key functions of RAET1L is its role in regulating the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6. These cytokines are important for the recruitment of immune cells to the site of inflammation , and for the initiation and execution of an inflammatory response. RAET1L has been shown to play a critical role in the regulation of their production, as well as their effects on the immune system.

In addition to its role in inflammation, RAET1L is also involved in the regulation of cell signaling pathways that are important for cell growth, differentiation, and survival. It has been shown to play a critical role in the regulation of angiogenesis, the formation of new blood vessels, and the regulation of vascular permeability.

Furthermore, RAET1L is also involved in the regulation of pain perception and neuroinflammation. Studies have shown that RAET1L is involved in the modulation of pain sensitivity, and that its activation can contribute to neuroinflammation.

RAET1L is also a potential biomarker for various diseases, including chronic obstructive pulmonary disease (COPD), asthma, and allergies. The levels of RAET1L have been shown to be elevated in individuals with these conditions, and studies have shown that inhibiting RAET1L can be an effective strategy for treating these diseases.

In conclusion, RAET1L is a protein that is involved in a wide range of cellular processes that are important for maintaining the health and function of the respiratory system. Its role in the regulation of inflammation, cell signaling pathways, angiogenesis, pain perception, and neuroinflammation makes it an attractive target for drug development. Further studies are needed to fully understand the role of RAET1L in these processes, as well as its potential as a biomarker for various diseases.

Protein Name: Retinoic Acid Early Transcript 1L

Functions: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity

The "RAET1L Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RAET1L comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets