E2F3: A Drug Target / Disease Biomarker (G1871)

Target Name: E2F3

NCBI ID: G1871

E2F3

E2F3: A Drug Target / Disease Biomarker

E2F3, also known as enterokinase 3, is a protein that plays a critical role in the regulation of DNA replication and cell growth. It is a key enzyme in the transcription factor factor E2F, which is a protein that binds to DNA and regulates gene expression. E2F3 is a 22kDa protein that is expressed in all cell types and is involved in the transcription of over 20% of human gene expression.

One of the key functions of E2F3 is its role in DNA replication. During DNA replication, E2F3 is involved in the formation of the double helix by catalyzing the recruitment of the four core subunits of the DNA replication complex to the site of the DNA double helix. This event is critical for the formation of a stable and functional double helix, which ensures the accurate transmission of genetic information from one generation to the next.

Another important function of E2F3 is its role in cell growth and differentiation. E2F3 is involved in the regulation of cell cycle progression, as well as the regulation of cell growth and differentiation. It is one of the key enzymes in the G1 phase of the cell cycle, during which the cell prepares for cell division by producing copies of its genetic material and increasing its size.

In addition to its role in cell cycle progression, E2F3 is also involved in the regulation of cell survival. E2F3 has been shown to play a critical role in the regulation of cell survival and has been linked to the development of various types of cancer. For example, studies have shown that high levels of E2F3 are associated with poor prognosis in breast cancer.

Despite its importance, E2F3 is not well understood. little is known about the specific functions of E2F3 and its role in the cell. There are only a few studies that have investigated its role in different biological processes, and more research is needed to fully understand its functions and potential as a drug target.

In conclusion, E2F3 is a protein that plays a critical role in the regulation of DNA replication and cell growth. It is a key enzyme in the transcription factor E2F and is involved in the formation of the double helix, as well as the regulation of cell cycle progression and cell survival. Further research is needed to fully understand its functions and potential as a drug target.

Protein Name: E2F Transcription Factor 3

Functions: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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