ZNF660: A Potential Drug Target and Biomarker (G285349)

ZNF660: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. ZNF660, a specific ZNF protein, has been identified as a potential drug target and biomarker. In this article, we will explore the biology of ZNF660, its potential drug targeting potential, and its potential as a biomarker for various diseases.

ZNF660: Structure and Function

ZNF660 is a 21-kDa protein that contains a unique N-terminal zinc finger domain, a conserved C-terminal ZNF6 domain, and a variable N-terminus. The N-terminal zinc finger domain is responsible for the protein's unique structure and function. This domain is known for its ability to form a stable complex with various transcription factors, which allows ZNF660 to play a critical role in gene regulation.

The ZNF660 gene is located on chromosome 16q21 and has been implicated in various cellular processes, including cell growth, differentiation, and inflammation. ZNF660 has been shown to play a role in the regulation of cell cycle progression, apoptosis, and angiogenesis.

Potential Drug Target

ZNF660 has been identified as a potential drug target due to its unique structure and function. The N-terminal zinc finger domain and C-terminal ZNF6 domain are known for their ability to form stable complexes with transcription factors, making them potential targets for small molecules. Additionally, the variable N-terminus of ZNF660 has been shown to play a role in its stability and functions, which may make it more responsive to small molecules.

Several small molecules have been shown to interact with ZNF660, including inhibitors of the N-terminal zinc finger domain and the C-terminal ZNF6 domain. These small molecules have been shown to inhibit the activity of ZNF660 and its downstream targets, leading to the potential for a drug that can be used to treat diseases that are characterized by the over-expression or dysfunction of ZNF660.

Biomarker Potential

ZNF660 has also been identified as a potential biomarker for various diseases. Its unique structure and function make it an attractive candidate for diagnostic tools and theragnostic drugs. For example, ZNF660 has been shown to be overexpressed in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

In addition, ZNF660 has also been shown to play a critical role in the regulation of cell apoptosis, which is a critical process in the regulation of cell life cycle. Overexpression of ZNF660 has been shown to contribute to the increased sensitivity of cancer cells to apoptosis inhibitors, making it a potential biomarker for cancer diagnosis and treatment.

Conclusion

ZNF660 is a unique protein that has been shown to play a critical role in various cellular processes. Its N-terminal zinc finger domain and C-terminal ZNF6 domain make it a potential target for small molecules, and its variable N-terminus has been shown to play a role in its stability and functions. Additionally, ZNF660 has been shown to be overexpressed in various diseases, making it a potential biomarker for these diseases.

The unique structure and function of ZNF660 make it an attractive candidate for drug targeting and biomarker development. Further research is needed to fully understand the biology of ZNF660 and its potential as a drug target and biomarker.

Protein Name: Zinc Finger Protein 660

Functions: May be involved in transcriptional regulation

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
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More Common Targets

ZNF662 | ZNF663P | ZNF664 | ZNF664-RFLNA | ZNF665 | ZNF667 | ZNF667-AS1 | ZNF668 | ZNF669 | ZNF670 | ZNF670-ZNF695 | ZNF671 | ZNF672 | ZNF674 | ZNF674-AS1 | ZNF675 | ZNF676 | ZNF677 | ZNF678 | ZNF679 | ZNF680 | ZNF681 | ZNF682 | ZNF683 | ZNF684 | ZNF687 | ZNF688 | ZNF689 | ZNF69 | ZNF691 | ZNF692 | ZNF695 | ZNF696 | ZNF697 | ZNF699 | ZNF7 | ZNF70 | ZNF700 | ZNF701 | ZNF702P | ZNF703 | ZNF704 | ZNF705A | ZNF705B | ZNF705CP | ZNF705EP | ZNF705G | ZNF706 | ZNF707 | ZNF708 | ZNF709 | ZNF71 | ZNF710 | ZNF711 | ZNF713 | ZNF714 | ZNF716 | ZNF717 | ZNF718 | ZNF721 | ZNF723 | ZNF724 | ZNF726 | ZNF727 | ZNF728 | ZNF729 | ZNF730 | ZNF732 | ZNF734P | ZNF735 | ZNF736 | ZNF737 | ZNF738 | ZNF74 | ZNF740 | ZNF746 | ZNF747 | ZNF749 | ZNF750 | ZNF75A | ZNF75CP | ZNF75D | ZNF76 | ZNF761 | ZNF763 | ZNF764 | ZNF765 | ZNF766 | ZNF767P | ZNF768 | ZNF77 | ZNF770 | ZNF771 | ZNF772 | ZNF773 | ZNF774 | ZNF775 | ZNF776 | ZNF777 | ZNF778