Target Name: ZNF641
NCBI ID: G121274
Review Report on ZNF641 Target / Biomarker Content of Review Report on ZNF641 Target / Biomarker
ZNF641
Other Name(s): Zinc finger protein 641 (isoform 1) | Zinc finger protein 641, transcript variant 1 | ZN641_HUMAN | ZNF641 variant 1 | zinc finger protein 641 | Zinc finger protein 641

ZNF641: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. ZNF641, also known as Zinc finger protein 641 (isoform 1), is a ZFP that is expressed in various tissues and cell types. It is characterized by the presence of a zinc finger domain and a unique N-terminus that contains a conserved nucleotide sequence. ZNF641 has been identified as a potential drug target and biomarker due to its unique structure and function.

The zinc finger domain is a conserved region that is characterized by the presence of a nucleotide sequence that is similar to the zinc finger motif. This motif is known to play a crucial role in the regulation of gene expression and is found in various proteins, including ZNF641. The N-terminus of ZNF641 contains a unique sequence that is conserved in many ZFPs, but is highly variable in the context of different cell types and tissues.

Expression and Localization of ZNF641

ZNF641 is expressed in various tissues and cell types, including neurons, liver cells, and muscle cells. It is also expressed in various developmental stages, including fetal and adult tissues. ZNF641 is primarily expressed in the cytoplasm of cells, but is also found in the endoplasmic reticulum (ER) and the nuclear envelope (NE).

Function and Interaction of ZNF641

The unique structure of ZNF641 has led to the conclusion that it plays a role in various cellular processes. ZNF641 is involved in the regulation of cell adhesion, as it has been shown to interact with the adhesion molecule E-cadherin. This interaction between ZNF641 and E-cadherin suggests that it may be involved in the regulation of cell-cell adhesion, which is a critical process in various tissues and cell types.

In addition to its role in cell adhesion, ZNF641 has also been shown to be involved in the regulation of cell proliferation. It has been shown to play a role in the G1/S transition, which is a critical stage in the cell cycle where cells prepare for cell division. ZNF641 has also been shown to interact with the cyclin D1 protein, which is a key regulator of the G1/S transition.

Potential Therapeutic Applications of ZNF641

The unique structure and function of ZNF641 make it an attractive drug target. ZNF641 has been shown to interact with small molecules, including inhibitors of the protein kinase A3 (PKA), which is a crucial regulator of cell proliferation. Additionally, ZNF641 has been shown to interact with the transcription factor p53, which is involved in the regulation of cell growth and apoptosis.

One potential approach to treating diseases that are characterized by the over-expression of ZNF641 is to target the protein itself. This can be done through various methods, including small molecule inhibitors, RNA interference, or CRISPR/Cas9 genome editing. By inhibiting the activity of ZNF641, it is possible to reduce the over-expression of the protein and potentially treat the underlying disease.

Another potential approach to treating diseases associated with ZNF641 over-expression is to use antibodies that specifically target the protein. These antibodies would be able to bind to ZNF641 and prevent it from interacting with its downstream targets, including E-cadherin and p53. By using antibodies to target

Protein Name: Zinc Finger Protein 641

Functions: Transcriptional activator. Activates transcriptional activities of SRE and AP-1

The "ZNF641 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF641 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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