Target Name: ZNF638
NCBI ID: G27332
Review Report on ZNF638 Target / Biomarker Content of Review Report on ZNF638 Target / Biomarker
ZNF638
Other Name(s): NP220 | zinc finger protein 638 | ZN638_HUMAN | ZNF638 variant 1 | Cutaneous T-cell lymphoma-associated antigen se33-1 | Nuclear protein 220 | Zinc finger protein 638 (isoform 1) | Zinc finger matrin-like protein | Zinc finger protein 638, transcript variant 1 | Zinc finger matrin-like | MGC26130 | NP220 nuclear protein | CTCL-associated antigen se33-1 | nuclear protein 220 | Zfp638 | MGC90196 | zinc finger matrin-like protein | Zinc finger protein 638 | ZFML | DKFZp686P1231 | cutaneous T-cell lymphoma-associated antigen se33-1 | CTCL tumor antigen se33-1

ZNF638 Interacts with Multiple Proteins: Potential Drug Targets

ZNF638 (NP220) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the ZNF6 gene family, which is known for its role in the development and maintenance of neural stem cells and their differentiated derivatives. ZNF638 has been shown to play a role in a variety of physiological processes in the body, including cell survival, proliferation, and migration.

One of the unique features of ZNF638 is its ability to interact with other proteins, particularly the transcription factor p53. p53 is a well-known protein that plays a critical role in regulating gene expression and cell survival. ZNF638 has been shown to physically interact with p53, and this interaction has been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis (programmed cell death), and inflammation.

In addition to its interaction with p53, ZNF638 has also been shown to interact with several other proteins, including the transcription factor NF-kappa-B (nuclear factor kappa B). NF-kappa-B is a transcription factor that plays a role in the regulation of various cellular processes, including inflammation, pain, and sleep. ZNF638 has been shown to physically interact with NF-kappa-B, and this interaction has been shown to play a role in the regulation of cellular processes such as inflammation, pain perception, and sleep.

ZNF638 has also been shown to interact with the protein known as PDGF-BB (Platelet-derived growth factor-basic), which is a potent regulator of cell proliferation and survival. PDGF-BB has been shown to play a role in the development and maintenance of various tissues, including blood vessels, neural stem cells, and cancer cells. ZNF638 has been shown to physically interact with PDGF-BB, and this interaction has been shown to play a role in the regulation of cellular processes such as cell proliferation, migration, and survival.

In conclusion, ZNF638 is a protein that has been shown to interact with several other proteins, including p53, NF-kappa-B, and PDGF-BB. These interactions have been shown to play a role in the regulation of various cellular processes, including cell survival, proliferation, and migration. As a result, ZNF638 may be a drug target or biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Further research is needed to fully understand the role of ZNF638 in these diseases, as well as to develop new therapeutic approaches for these conditions.

Protein Name: Zinc Finger Protein 638

Functions: Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity)

The "ZNF638 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF638 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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