FAM76A: A Potential Drug Target and Biomarker (G199870)

Target Name: FAM76A

NCBI ID: G199870

FAM76A

FAM76A: A Potential Drug Target and Biomarker

FAM76A, also known as ABCG2, is a gene that encodes a protein involved in the regulation of amino acid transport and metabolism in the body. The protein encoded by FAM76A is a member of the ATP-binding Cassette (ABC) family, which is a transmembrane protein family that plays a crucial role in the regulation of intracellular signaling pathways. ABCG2 is a 21-kDa protein that consists of an N-terminal transmembrane domain, a catalytic domain, and a C-terminal cytoplasmic domain.

The N-terminal transmembrane domain of FAM76A is composed of a single constant region and a variable region that contains multiple putative transmembranespanning domains (TMDs). The N-terminal region of FAM76A contains a putative N-end rule protein (NER) domain, which is known to play a role in the regulation of protein stability and localization to the plasma membrane.

The catalytic domain of FAM76A contains a single active site that is residue- specific for the ATP. This domain is responsible for the catalytic activity of FAM76A, which is to bind to and regulate the activity of various ABCG2s. The catalytic domain of FAM76A contains several distinct regions, including a nucleotide-binding site (NBS), a glutamic acid-binding site (GABS), and a putative ATP-binding site (ABS).

The C-terminal cytoplasmic domain of FAM76A is composed of a single region that contains a putative cytoplasmic localization signal (CLS) and a putative protein-interaction domain (PID). The CLS is a short region that is involved in the localization of FAM76A to the cytoplasm, and the PID is a region that is involved in protein-protein interactions.

Several studies have identified potential drug targets and biomarkers associated with FAM76A. One of the most promising potential drug targets for FAM76A is the inhibition of FAM76A activity, which could lead to the inhibition of protein transport and metabolism, and potentially result in the accumulation of toxic substances in cells.

Another potential biomarker for FAM76A is the measurement of the expression level of FAM76A in cancer cells. Cancer cells often have increased expression of FAM76A compared to normal cells, and this increased expression can be used as a biomarker for the presence and progression of cancer.

FAM76A has also been shown to play a role in the regulation of cellular processes, including cell adhesion, migration, and invasion. In addition, FAM76A has also been shown to play a role in the regulation of cellular signaling pathways, including the TGF-β pathway.

Overall, FAM76A is a gene that has the potential to be a drug target and biomarker in a variety of diseases. Further research is needed to fully understand the role of FAM76A in cellular processes and to develop effective strategies for the inhibition of FAM76A activity.

Protein Name: Family With Sequence Similarity 76 Member A

The "FAM76A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FAM76A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets