FANCM: A Protein Involved in Endocytosis and Drug Delivery (G57697)

Target Name: FANCM

NCBI ID: G57697

FANCM

FANCM: A Protein Involved in Endocytosis and Drug Delivery

FANCM, or FAN-CM, is a protein that is expressed in the human endocytosis system, which is responsible for the internalization of proteins into the cell. FANCM has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The endocytosis system is a complex process that involves the delivery of proteins from the cell surface to the cytoplasm. This process is critical for the survival of many cell types, as it allows them to internalize foreign substances, such as viruses and bacteria, and to eliminate them via the phagocytic system. The endocytosis system is also involved in the delivery of proteins for maintenance and regulation of cellular processes, such as signaling pathways and cellular signaling networks.

FANCM is a member of the endocytosis-related protein (ERP) family, which includes proteins that are involved in the delivery of various types of molecules to the cytoplasm. FANCM is characterized by its unique structure and function, as it is able to internalize proteins in a specific manner, which is not well understood.

One of the key functions of FANCM is its ability to internalize proteins with specific affinity. This is achieved through a unique conformational change that allows FANCM to form a stable complex with certain proteins. This process is known as endocytosis-triggered internalization (ETI), and it is a critical step in the endocytosis system.

FANCM has been shown to play a role in the delivery of a variety of proteins to the cytoplasm, including proteins involved in cell signaling pathways, such as tyrosine kinase receptor, G protein-coupled receptor, and ion channels. It has also been shown to be involved in the delivery of intracellular signaling molecules, such as protein kinase inhibitors, neurotransmitters, and hormones.

FANCM has also been shown to be involved in the regulation of cellular processes, including cell division, apoptosis, and inflammation. It has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its role in cellular processes, FANCM has also been shown to be involved in the delivery of drugs to the endosome, which is a specialized organelle that is involved in the internalization of proteins. This is important for the development of drug-conjugated nanoparticles, which have the potential to be used for various applications, including drug delivery, bioconjugation, and imaging.

FANCM has also been shown to be involved in the regulation of cellular signaling networks, including the TGF-β pathway. This pathway is involved in the regulation of cellular processes, including cell growth, differentiation, and inflammation. FANCM has been shown to play a role in the regulation of TGF-β signaling by affecting the activity of the transcription factor, SMAD.

In conclusion, FANCM is a protein that is involved in the endocytosis system and has been shown to play a role in the delivery of proteins to the cytoplasm. Its unique conformational change and its involvement in cellular processes, including cell signaling pathways and the regulation of cellular signaling networks make it an attractive drug target and a biomarker for various diseases. Further research is needed to fully understand the role of FANCM in cellular processes and its potential as a drug target.

Protein Name: FA Complementation Group M

Functions: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434)

The "FANCM Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FANCM comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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