Structure and Function of ADAM10-processed FasL (G356)

Target Name: FASLG

NCBI ID: G356

FASLG

Structure and Function of ADAM10-processed FasL

FasL (fas-like protein 1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, lungs, and gastrointestinal tract. It is a key regulator of cell survival and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Despite its importance, little is known about the structure and function of FasL.

ADAM10-processed FasL (ADAM10-processed FasL form) is a variant of FasL that has been processed by the ADAM10 enzyme. This processed form of FasL has been shown to have unique properties and functions compared to the original form. In this article, we will explore the structure and function of ADAM10-processed FasL, as a potential drug target or biomarker.

Structure and Function of ADAM10-processed FasL

The structure of ADAM10-processed FasL is similar to that of wild-type FasL. It consists of a 21-kDa protein that contains 198 amino acid residues. The protein has a molecular weight of 21 kDa and a calculated pI of 4.8.

One of the key differences between ADAM10-processed FasL and wild-type FasL is the presence of the amino acid Asp112. In wild-type FasL, Asp112 is replaced by Asp111, which is a key residue that is involved in the formation of the protein-protein interaction network. In ADAM10-processed FasL, Asp112 is still present but has been modified.

Another difference between the two forms of FasL is the presence of the amino acid Asn113. In wild-type FasL, Asn113 is replaced by Asp112, which is also a key residue that is involved in the formation of the protein-protein interaction network. In ADAM10-processed FasL, Asn113 is present in the same way as Asp112.

The structure of ADAM10-processed FasL has been determined through a combination of biochemical, molecular, and structural studies. These studies have shown that ADAM10-processed FasL has a similar three-dimensional structure to wild-type FasL, but with some differences.

Function of ADAM10-processed FasL

ADAM10-processed FasL has been shown to have unique functions compared to wild-type FasL. One of the most significant functions of ADAM10-processed FasL is its ability to induce cell death. This is accomplished through the formation of a protein-protein interaction network, which results in the production of reactive oxygen species (ROS) that can damage cellular components and lead to cell death.

In addition to its ability to induce cell death, ADAM10-processed FasL has also been shown to have a number of other functions. For example, it has been shown to play a role in the regulation of cell adhesion, cell migration, and the development of cancer. It has also been shown to be involved in the regulation of inflammation and the immune response.

Despite its importance, little is known about the underlying mechanisms that regulate the function of ADAM10-processed FasL. Further research is needed to fully understand the functions of this protein and its potential as a drug target or biomarker.

Conclusion

ADAM10-processed FasL is a variant of FasL that has been processed by the ADAM10 enzyme. It has a similar three-dimensional structure to wild-type FasL but with some differences, including the presence of the amino acid Asn113. ADAM10-processed FasL has been shown to have unique functions, including the ability to induce cell death and to play a role in the regulation of cell adhesion, cell migration, and the development of cancer. Further research is needed to fully understand the functions of this protein and its potential as a drug target or biomarker.

Protein Name: Fas Ligand

Functions: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260)

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