PASK: A Potential Drug Target and Biomarker for Serine/Threonine-Protein Kinase (ISO Form 1)

Target Name: PASK

NCBI ID: G23178

PASK

PASK: A Potential Drug Target and Biomarker for Serine/Threonine-Protein Kinase (ISO Form 1)

Introduction

Serine/threonine-protein kinase (ISO Form 1) is a family of enzyme that plays crucial roles in various cellular processes, including cell signaling, protein folding, and intracellular signaling. ISO Form 1 is composed of a unique catalytic core and a distinct N -terminus that includes a P-loop and a C-terminus. The P-loop is a conserved region that is commonly found in proteins that exhibit multiple substrate-specificity, while the C-terminus is unique to ISO Form 1 and is involved in its catalytic activity and interactions with other cellular components.

Recent studies have identified PASK (PAS domain-containing serine/threonine-protein kinase) as a potential drug target and biomarker for ISO Form 1-mediated signaling pathways. PASK is a protein that is expressed in various cell types, including neurons, heart, and cancer cells. It is highly conserved, with a similar structure to ISO Form 1, and has been shown to catalyze a wide range of serine/threonine protein substrates with exceptional specificity and catalytic activity.

The PASK enzyme has been shown to play a crucial role in various cellular processes, including cell signaling, protein folding, and intracellular signaling. PASK is a protein that is expressed in various cell types, including neurons, heart, and cancer cells. It is Highly conserved, with a similar structure to ISO Form 1, and has been shown to catalyze a wide range of serine/threonine protein substrates with exceptional specificity and catalytic activity.

PASK has been shown to play a role in various signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. PASK has also been shown to regulate the activity of other enzymes, including the protein kinase B (PKB) and the protein kinase C (PKC).

In addition to its role in cellular signaling, PASK has also been shown to have potential as a drug target. Several studies have shown that PASK is highly mutable and can be targeted by small molecules. In addition, several studies have shown that PASK inhibitors can block the activity of ISO Form 1 and its downstream targets, including the protein kinase B and the transcription factor PDGF-尾.

Furthermore, recent studies have shown that PASK can be used as a biomarker for various diseases, including cancer. In addition, PASK has been shown to be involved in the regulation of various cellular processes, including cell signaling, protein folding, and intracellular signaling.

Conclusion

In conclusion, PASK is a protein that has been shown to play a crucial role in various cellular processes, including cell signaling, protein folding, and intracellular signaling. Its unique catalytic core and distinct N-terminus make it a potential drug target and biomarker for ISO Form 1-mediated signaling pathways. Further studies are needed to fully understand the role of PASK in cellular signaling and its potential as a drug target and biomarker for various diseases.

Protein Name: PAS Domain Containing Serine/threonine Kinase

Functions: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation

The "PASK Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PASK comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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