DIP2A: A Potential Drug Target and Biomarker for Disco-Interacting Protein 2 Homolog A

Target Name: DIP2A

NCBI ID: G23181

DIP2A

DIP2A: A Potential Drug Target and Biomarker for Disco-Interacting Protein 2 Homolog A

Abstract:

Disco-Interacting Protein 2 (DIP2) is a key regulator of the ubiquitin system, which is involved in various cellular processes, including cell division, apoptosis, and inflammation. DIP2A, a splice variant of DIP2, has been shown to interact with multiple protein partners, including other disco-interacting proteins (DISCs) and non-disco-interacting proteins (NDI). In this article, we discuss the potential implications of DIP2A as a drug target and biomarker for various diseases.

Introduction:

Disko-Interacting Protein 2 (DIP2) is a protein that plays a critical role in the regulation of the ubiquitin system, a complex protein-protein interaction network that involves the ubiquitin covalent attachment of protein labels to target proteins for degradation. DIP2 is a 21 -kDa protein that consists of an N-terminal domain with a putative nuclear export signal, a middle domain with a ubiquitin-like domain, and a C-terminal domain with a conserved T-cell receptor (TCR) domain. DIP2 has been shown to interact with a variety of protein partners, including other DISCs and NDI.

DIP2A Interactions with DISCs:

DIP2A has been shown to interact with multiple DISCs, including histone-associated protein (HAP) 2, which is a key regulator of the chromatin-remodeling complex (CRC) and is involved in the regulation of DNA replication, gene expression, and cell growth . DIP2A has also been shown to interact with the transcription factor, p53, which is involved in the regulation of DNA replication, gene expression, and cell growth.

DIP2A Interactions with NDI:

DIP2A has also been shown to interact with several NDIs, including the protein, heat shock protein (HSP)70, which is involved in the regulation of protein folding and stability, and the protein, p16INK4a, which is involved in the regulation of cell growth and apoptosis.

Potential Drug Targets and Biomarkers:

DIP2A has been shown to play a critical role in the regulation of various cellular processes, including cell division, apoptosis, and inflammation. Therefore, it is a potential drug target for various diseases.

One potential drug target for DIP2A is the inhibition of DIP2A activity, which could lead to the accumulation of DIP2A in the cells and the regulation of various cellular processes. This could be achieved through various mechanisms, including inhibition of the activity of DIP2A by small molecules , such as inhibitors of protein-protein interactions (PPIs), or by inhibition of the activity of DIP2A by antibodies.

Another potential biomarker for DIP2A is the measurement of the levels of DIP2A in the cells. This could be done by various techniques, including Western blotting, immunoblotting, or mass spectrometry. The levels of DIP2A could be used as a proxy for the activity of DIP2A and could be used to monitor the efficacy of drugs that target DIP2A.

Conclusion:

In conclusion, DIP2A is a protein that plays a critical role in the regulation of the ubiquitin system and has been shown to interact with multiple protein partners, including DISCs and NDI. The potential drug targets for DIP2A include the inhibition of its activity, which could lead to the regulation of various cellular processes, and the measurement of its levels, which could be used as a biomarker for the efficacy of drugs. Further research is needed to fully understand the role of DIP2A in the regulation of cellular processes and to develop effective drug targets and biomarkers for this protein.

Protein Name: Disco Interacting Protein 2 Homolog A

Functions: Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002)

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•   general information;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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