CLUH: A Protein Involved in Cell Adhesion, Migration and Ion & Water Transport

Target Name: CLUH

NCBI ID: G23277

CLUH

CLUH: A Protein Involved in Cell Adhesion, Migration and Ion & Water Transport

CLUH (Uncharacterized LOC105371591) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the C-type water-splitting cytoskeleton protein family, which is characterized by the presence of a unique water-splitting domain in the protein sequence.

The C-type water-splitting cytoskeleton protein family is a subset of the larger cytoskeleton protein family, which includes proteins that are involved in the cytoskeleton structure and function. These proteins are characterized by the presence of a unique C-type domain, which is responsible for the water-splitting reaction that allows the cytoskeleton to move and change shape.

CLUH is a 12kDa protein that is expressed in the brain, heart, and kidneys. It is highly conserved, with a calculated pI of 11.0 and a predicted localization in the cytoplasm. CLUH is also known as UNC-1729 and HSP703.2.

CLUH is involved in various cellular processes, including cell adhesion, migration, and the regulation of ion and water transport. It is also involved in the formation of the cytoskeleton and in the regulation of cell cycle progression.

One of the unique features of CLUH is its ability to form a stable complex with the cytoskeleton protein F-actinin. This complex plays a role in regulating the distribution and activity of various cytoskeleton proteins, including microtubules and other cytoskeleton components.

In addition to its role in cytoskeleton regulation, CLUH is also involved in the regulation of cell adhesion and migration. It has been shown to play a role in the regulation of tight junction formation and the migration of various cell types, including cancer cells.

CLUH is also involved in the regulation of ion and water transport. It has been shown to play a role in the regulation of intracellular ion levels and in the regulation of water transport into and out of cells.

In conclusion, CLUH is a highly conserved protein that is involved in various cellular processes, including cell adhesion, migration, and the regulation of ion and water transport. Its unique C-type water-splitting domain and its ability to form a stable complex with the cytoskeleton protein F-actinin make it an attractive drug target and a potential biomarker for various diseases. Further research is needed to fully understand the role of CLUH in cellular processes and its potential as a drug target.

Protein Name: Clustered Mitochondria Homolog

Functions: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis

The "CLUH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CLUH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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