FOSB: A Protein Targeted for Cancer and Neurodegenerative Diseases

Target Name: FOSB

NCBI ID: G2354

FOSB

FOSB: A Protein Targeted for Cancer and Neurodegenerative Diseases

FOSB, or Protein FosB (isoform 1), is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of cell growth, differentiation, and survival, and is involved in a wide range of physiological processes, including cell signaling, protein synthesis, and stress response.

FOSB has been identified as a potential drug target due to its involvement in a number of diseases and conditions, including cancer, neurodegenerative diseases, and chronic kidney disease. It is also a good candidate as a biomarker for tracking disease progression and response to treatment.

One of the key challenges in studying FOSB is its complex structure and function. FOSB is a large protein that contains multiple domains, including an N-terminus, a T-terminus, and a middle body that contains multiple conserved structural motifs. The terminus of FOSB contains a region that is highly conserved and is involved in protein-protein interactions, while the T-terminus contains a region that is also highly conserved and is involved in ligand binding.

The middle body of FOSB is the most variable and contains multiple conserved structural motifs, such as a conserved 伪-helix, 尾-sheet and helix-helix structure. The interaction of these domains enables FOSB to form a stable three-dimensional structure and participate in a variety of biological processes.

Research shows that FOSB plays an important role in a variety of diseases, including neurodegenerative diseases, diabetes, obesity, hypertension and cancer. In these diseases, aberrant expression or dysfunction of FOSB may contribute to disease progression and increased severity. For example, studies have shown that the expression level of FOSB is positively correlated with the quality of life and survival rate of patients with neurodegenerative diseases, and the expression level of FOSB is positively correlated with the quality of life and survival rate of patients with neurodegenerative diseases.

In addition, FOSB is closely related to many important biological processes, including cell proliferation, differentiation, and apoptosis. Studies have shown that FOSB plays a key role in regulating the cell cycle, cell proliferation and apoptosis.

In addition, FOSB is closely related to many important molecular mechanisms, including cell signaling

Protein Name: FosB Proto-oncogene, AP-1 Transcription Factor Subunit

Functions: Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:12618758, PubMed:28981703). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Exhibits transactivation activity in vitro (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity)

The "FOSB Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FOSB comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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