FOXI2: A Non-Coding RNA Molecule with Potential Drug Interaction

Target Name: FOXI2

NCBI ID: G399823

FOXI2

FOXI2: A Non-Coding RNA Molecule with Potential Drug Interaction

Forkhead box I2 (FOXI2) is a non-coding RNA molecule that is expressed in various tissues and cells throughout the body.FOXI2 has been identified as a potential drug target and has been shown to play a role in a variety of biological processes, including cell signaling, DNA replication, and repair.

History of Discovery

FOXI2 was first identified in the early 1990s as a Highly Expressed gene (HEG) in the mouse brain. It is composed of 251 amino acid residues and has a unique open reading frame that encodes a protein with a forkhead-like structure.FOXI2 has since has been shown to be expressed in a variety of tissues and cells throughout the body, including brain, heart, skeletal muscle, and various organs.

Function and Mechanism of Action

FOXI2 is a key regulator of DNA replication and repair. It is involved in the repair of DNA double-strand breaks, as well as the regulation of DNA replication initiation and elision.FOXI2 has been shown to play a role in the regulation of cell cycle progression, and is thus thought to be involved in the development and progression of cancer.

FOXI2 has also been shown to play a role in cell signaling. It is a negative regulator of the sprouting angiogenesis factor (SAG) gene, which is involved in the formation of new blood vessels. FOXI2 has also been shown to regulate the activity of the transcription factor, NF-kappa-B, and to play a role in the regulation of inflammation.

Drug Interaction with FOXI2

FOXI2 has been shown to be a potential drug target, and a number of compounds have been shown to interact with it. One of the most well-known compounds is the drug, tamoxifen, which is an inhibitor of the estrogen receptor. Tamoxifen has been shown to inhibit the activity of FOXI2, and thus may be a useful therapy for the treatment of breast cancer.

Another compound that has been shown to interact with FOXI2 is the drug, curcumin, which is an antioxidant that is derived from the curcuma plant. Curcumin has been shown to inhibit the activity of FOXI2 and may be a useful therapy for the treatment of various diseases , including cancer.

Conclusion

FOXI2 is a non-coding RNA molecule that is expressed in various tissues and cells throughout the body. FOXI2 has been shown to play a role in a variety of biological processes, including cell signaling, DNA replication, and repair. It is a potential drug target and has been the subject of a number of studies aimed at identifying small molecules that can interact with it. Further research is needed to fully understand the role of FOXI2 in biology and to develop effective therapies based on it.

Protein Name: Forkhead Box I2

Functions: Possible transcriptional activator

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