TSPAN12: A Potential Drug Target and Biomarker (G23554)

Target Name: TSPAN12

NCBI ID: G23554

TSPAN12

TSPAN12: A Potential Drug Target and Biomarker

Tetraspanin-12 (TSPAN12) is a protein that is expressed in various cell types, including neurons, glial cells, and endothelial cells. It is a member of the tetraspanin family, which are a group of transmembrane proteins that play a variety of roles in cellular signaling and structure. TSPAN12 has been shown to be involved in a number of cellular processes, including cell signaling, cell adhesion, and cell survival.

One of the key functions of TSPAN12 is its role in cell signaling. TSPAN12 has been shown to be involved in a variety of signaling pathways, including the regulation of cell proliferation, differentiation, and survival. For example, studies have shown that TSPAN12 can be regulated by various signaling pathways, including TGF-β, Wnt, and Notch. These signaling pathways are important for the development and maintenance of neural stem cells, and TSPAN12 may be a potential drug target for these therapies.

Another function of TSPAN12 is its role in cell adhesion. TSPAN12 is involved in the formation of tight junctions, which are a type of cell-cell adhesion structure that helps to maintain the integrity of the intercellular space. TSPAN12 has been shown to be involved in the regulation of tight junction formation and may be a potential drug target for therapies that target cell-cell adhesion.

In addition to its role in cell signaling and adhesion, TSPAN12 is also involved in cell survival. TSPAN12 has been shown to play a role in the regulation of cell cycle progression, which is important for the maintenance of cellular stability and the regulation of cellular processes that are necessary for cell survival.

The potential drug targets for TSPAN12 are numerous. For example, TSPAN12 has been shown to be involved in the regulation of cell proliferation, which is a potential drug target for therapies that target cancer. TSPAN12 may also be a potential drug target for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as it is involved in the regulation of cellular processes that are important for the maintenance of neural stem cells and the development of the nervous system.

In addition to its potential drug targets, TSPAN12 is also a potential biomarker. The expression of TSPAN12 has been shown to be involved in the regulation of cellular processes that are important for the development and maintenance of neural stem cells. This may make TSPAN12 an attractive biomarker for the diagnosis and treatment of neurodegenerative diseases.

The discovery and characterization of TSPAN12 as a potential drug target and biomarker has important implications for the development of new therapies for a variety of diseases. Further research is needed to fully understand the role of TSPAN12 in cellular signaling and to develop effective therapies that target this protein.

Protein Name: Tetraspanin 12

Functions: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity

The "TSPAN12 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TSPAN12 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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