MRGPRX1: A GPCR Receptor for Neurotransmission and Stress (G259249)

Target Name: MRGPRX1

NCBI ID: G259249

MRGPRX1

MRGPRX1: A GPCR Receptor for Neurotransmission and Stress

MRGPRX1 (Mammalian G-protein-coupled receptor X1) is a protein that is expressed in various tissues of the human body, including the brain, heart, kidneys, and liver. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play an important role in cellular signaling.

The primary function of MRGPRX1 is to transmit signals from various extracellular stimuli, such as hormones and neurotransmitters, to the intracellular signaling pathway. This is accomplished through the interaction of the protein with specific GPCR signaling partners, which include various intracellular signaling molecules.

One of the unique features of MRGPRX1 is its extracellular domain, which consists of a long amino acid sequence that is involved in various signaling processes. This sequence is known as the extracellular domain (ECD), and it is thought to play a key role in the regulation of cellular signaling.

The ECD of MRGPRX1 contains several key structural elements, including a long amino acid tail that is involved in the formation of a protein-ligand complex with GPCR signaling partners. This tail is also known as the C-terminus, and it is thought to play a key role in the stability and activity of the protein.

In addition to its ECD, MRGPRX1 also has a unique structural feature known as a hypervariable region (HVR). This region is located between the N-terminus and the ECD and is responsible for the diversity of the protein. HVRs are often involved in the regulation of protein function and can vary significantly between different species.

The potential utility of MRGPRX1 as a drug target or biomarker is based on its involvement in various cellular signaling pathways. For example, MRGPRX1 has been shown to play a role in the regulation of neurotransmitter release from neurons, which is important for a variety of physiological processes, including mood regulation, learning, and memory.

In addition to its involvement in neurotransmission, MRGPRX1 has also been shown to play a role in the regulation of inflammation and cellular responses to stress. For example, studies have shown that MRGPRX1 is involved in the regulation of the production of pro-inflammatory cytokines, which are involved in the regulation of inflammation and immune responses.

The ability of MRGPRX1 to interact with multiple GPCR signaling partners also makes it an attractive candidate for drug targeting. By targeting specific GPCR signaling partners, drugs can be developed that specifically modulate the activity of MRGPRX1 and improve its therapeutic potential.

In conclusion, MRGPRX1 is a unique and highly promising protein that is involved in various cellular signaling pathways. Its extracellular domain, ECD, and HVR, as well as its ability to interact with multiple GPCR signaling partners make it an attractive candidate for drug targeting and biomarker development. Further research is needed to fully understand the role of MRGPRX1 in cellular signaling and its potential as a drug target or biomarker.

Protein Name: MAS Related GPR Family Member X1

Functions: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner

The "MRGPRX1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MRGPRX1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets