MRPS10: A Potential Drug Target and Biomarker for Mitochondrial Function

Target Name: MRPS10

NCBI ID: G55173

MRPS10

MRPS10: A Potential Drug Target and Biomarker for Mitochondrial Function

Mitochondria are organelles responsible for generating energy in the form of ATP in eukaryotic cells. They are also involved in the production of various molecules, including proteins, lipids, and nucleic acids. One of the proteins produced by mitochondria is the 28S ribosomal protein S10 (MRPS10), which plays a crucial role in regulating mitochondrial structure and function. In this article, we will discuss the potential drug target and biomarker properties of MRPS10.

Structure and Function

The 28S ribosomal protein S10 is a key component of the mitochondrial ribosome, which is the largest protein complex found in the cell. It consists of 254 amino acids and has a calculated molecular mass of 33 kDa. The protein has a distinct N-terminus, a transmembrane region, and a C-terminus that is involved in interactions with various cellular signaling pathways.

MRPS10 functions as a structural protein that helps maintain the stability of the ribosome. It plays a critical role in regulating the size and shape of the ribosome, allowing for the efficient translation of mRNAs into the cytoplasm. In addition, MRPS10 is involved in the regulation of mitochondrial fission, which is critical for the process of cell division.

Drug Targeting

The potential drug targeting of MRPS10 is based on its unique structure and the various functions it plays in the cell. One of the main targets of drug development for MRPS10 is the inhibition of its activity, which would lead to the disruption of normal cellular processes and potentially lead to therapeutic benefits.

An inhibitor of MRPS10, such as tirapazam, has been shown to reduce the formation of mitochondrial fission and to decrease the amount of mitochondrial protein S10 that is present in the cell. This suggests that tirapazam could be an effective drug against certain diseases caused by the overproduction or dysfunction of MRPS10, such as cancer, neurodegenerative diseases, and cardiovascular diseases.

Biomarker

The abundance and activity of MRPS10 can be used as a biomarker for various diseases. For example, increased levels of MRPS10 have been observed in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, decreased levels of MRPS10 have been observed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

In addition to its use as a biomarker, MRPS10 may also be used as a drug target in neurodegenerative diseases. The disruption of normal cellular processes caused by the dysfunction of MRPS10 could provide a target for therapeutic intervention and potentially lead to the development of new treatments for neurodegenerative diseases.

Conclusion

MRPS10 is a protein produced by the mitochondria that plays a crucial role in regulating mitochondrial structure and function. Its unique structure and the various functions it plays in the cell make it an attractive target for drug development. The inhibition of MRPS10 activity has been shown to be effective in the treatment of certain diseases caused by the overproduction or dysfunction of MRPS10. Additionally, MRPS10 may also be used as a biomarker for various types of cancer and neurodegenerative diseases. Further research is needed to fully understand the potential drug targeting and biomarker properties of MRPS10.

Protein Name: Mitochondrial Ribosomal Protein S10

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•   general information;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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