Target Name: MRPS27
NCBI ID: G23107
Review Report on MRPS27 Target / Biomarker Content of Review Report on MRPS27 Target / Biomarker
MRPS27
Other Name(s): RT27_HUMAN | MRPS27 variant 2 | KIAA0264 | Mitochondrial ribosomal protein S27, transcript variant 2 | Mitochondrial 28S ribosomal protein S27 | 28S ribosomal protein S27, mitochondrial | mitochondrial ribosomal protein S27 | 28S ribosomal protein S27, mitochondrial (isoform 2) | Mitochondrial ribosomal protein S27 | S27mt | MRP-S27 | mitochondrial 28S ribosomal protein S27 | mitochondrial small ribosomal subunit protein mS27 | Mitochondrial small ribosomal subunit protein mS27

Key Regulator of Splicing and Gene Expression in Various Tissues, Potential Drug Targets

MRPS27 (Mammalian Reticulostatin-Induced Spliceosome Recruitment) is a protein that is expressed in various tissues of the human body, including the brain, heart, and liver. It is a key regulator of splicing, a process that is responsible for generating the final RNA product from DNA templates. Mutations in the MRPS27 gene have been linked to a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, targeting this protein has become a promising strategy for the development of new treatments.

One of the key features of MRPS27 is its role in regulating splicing. Splicing is a process that is essential for the production of functional RNA molecules from DNA templates. In MRPS27, a spliceosome is a protein complex that recruits RNA splicing factors to the start of the exon to ensure that RNA is produced from the correct DNA template. This protein has been shown to play a critical role in regulating splicing in various tissues of the body, including the brain.

In addition to its role in splicing, MRPS27 has also been shown to be involved in the regulation of gene expression. This protein has been shown to interact with various RNA molecules, including RNA polymerase II, a protein that is involved in the production of RNA from DNA templates. This interaction between MRPS27 and RNA polymerase II suggests that MRPS27 may be a potential drug target for the development of RNA polymerase II inhibitors, which could be useful for treating a variety of diseases.

Another potential mechanism by which MRPS27 may be involved in the development of cancer is its role in the regulation of cellular apoptosis, a process that is cell death that is regulated by various signaling pathways. In cancer cells, the regulation of apoptosis can become imbalanced, leading to the survival and proliferation of cancer cells. MRPS27 has been shown to play a role in regulating apoptosis in various tissues of the body, including the brain. This suggests that targeting this protein may be a promising strategy for the development of new anti-cancer drugs.

In addition to its potential role in the regulation of apoptosis, MRPS27 has also been shown to be involved in the regulation of cellular signaling pathways. This protein has been shown to interact with various signaling molecules, including TGF-β1, a protein that is involved in the regulation of cellular growth and differentiation. This interaction between MRPS27 and TGF-β1 suggests that MRPS27 may be a potential drug target for the development of TGF-β1 inhibitors, which could be useful for treating a variety of diseases.

The MRPS27 gene has also been implicated in a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles. In MRPS27, mutations have been shown to play a role in the regulation of neurodegenerative diseases. This suggests that targeting this protein may be a promising strategy for the development of new treatments for these conditions.

In conclusion, MRPS27 is a protein that has been shown to play a critical role in regulating splicing and gene expression in various tissues of the human body. Its role in these processes makes it a potential drug target for the development of new treatments for a variety of diseases. Additionally, its involvement in the regulation of cellular apoptosis and signaling pathways suggests that it may be a useful target for the development of new anti-cancer drugs. Further research is needed to fully understand the role of MRPS27 in the development of disease and to identify its potential as a drug target.

Protein Name: Mitochondrial Ribosomal Protein S27

Functions: RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain (PubMed:22841715). Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:28714366)

The "MRPS27 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MRPS27 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

MRPS28 | MRPS30 | MRPS30-DT | MRPS31 | MRPS31P2 | MRPS31P4 | MRPS31P5 | MRPS33 | MRPS33P4 | MRPS34 | MRPS35 | MRPS35-DT | MRPS36 | MRPS36P4 | MRPS5 | MRPS6 | MRPS7 | MRPS9 | MRRF | MRS2 | MRS2P2 | MRTFA | MRTFB | MRTO4 | MS4A1 | MS4A10 | MS4A12 | MS4A13 | MS4A14 | MS4A15 | MS4A18 | MS4A2 | MS4A3 | MS4A4A | MS4A4E | MS4A5 | MS4A6A | MS4A6E | MS4A7 | MS4A8 | MSANTD1 | MSANTD2 | MSANTD3 | MSANTD4 | MSC | MSC-AS1 | MSGN1 | MSH2 | MSH3 | MSH4 | MSH5 | MSH5-SAPCD1 | MSH6 | MSI1 | MSI2 | MSL1 | MSL2 | MSL3 | MSL3P1 | MSLN | MSLNL | MSMB | MSMO1 | MSMP | MSN | MSNP1 | MSR1 | MSRA | MSRA-DT | MSRB1 | MSRB1P1 | MSRB2 | MSRB3 | MSRB3-AS1 | MSS51 | MST1 | MST1L | MST1P2 | MST1R | MSTN | MSTO1 | MSTO2P | MSX1 | MSX2 | MSX2P1 | MT1A | MT1B | MT1DP | MT1E | MT1F | MT1G | MT1H | MT1HL1 | MT1IP | MT1JP | MT1L | MT1M | MT1P1 | MT1P3 | MT1X