MRPL47: A Potential Drug Target and Biomarker (G57129)

Target Name: MRPL47

NCBI ID: G57129

MRPL47

MRPL47: A Potential Drug Target and Biomarker

MRP (MutL1 Receptor Protease) is a family of proteins that play a crucial role in the regulation of DNA damage repair, cell division, and apoptosis. The L47 subfamily of MRPs is composed of four proteins: MRPL47, MRPL48, MRPL49, and MRPL50. These proteins are involved in various cellular processes, including DNA double-strand break repair, single-strand repair, and apoptosis. MRPL47, also known as MLN1, is a member of the MRPL47 family and is known to function as a DNA double-strand break repair protein.

DNA double-strand break repair is a critical process that occurs when a double-strand break in the DNA occurs. This process involves the recruitment of several proteins, including MRPL47, to the site of the break. Once recruited, MRPL47 helps to facilitate the repair of the double-strand break by ensuring that the appropriate repair machinery is assembled at the site of the break.

In addition to its role in DNA double-strand break repair, MRPL47 has also been shown to play a key role in the regulation of cell apoptosis. Apoptosis is a natural and necessary process that occurs in the development and progression of many diseases, including cancer . MRPL47 has been shown to regulate the execution of apoptotic programs in various cell types, including cancer cells.

The potential drug targets for MRPL47 are numerous. One of the main targets is the inhibition of MRPL47, which could lead to the inhibition of DNA double-strand break repair and the regulation of cell apoptosis. This could have potential therapeutic applications in diseases such as cancer, where the regulation of DNA repair and apoptosis is disrupted.

Another potential drug target for MRPL47 is the inhibition of MRPL47-mediated DNA double-strand break repair. This could lead to the inhibition of the repair of DNA double-strand breaks and the development of DNA repair-deficient mutations. This could have therapeutic potential applications in diseases where DNA repair is impaired, such as in genetic disorders.

In addition to its potential therapeutic applications, MRPL47 is also a potential biomarker for several diseases. The regulation of DNA double-strand break repair and apoptosis is the precise

Protein Name: Mitochondrial Ribosomal Protein L47

The "MRPL47 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MRPL47 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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