HACL1: Regulating Microtubule Formation and Cell Signaling (G26061)

Target Name: HACL1

NCBI ID: G26061

HACL1

HACL1: Regulating Microtubule Formation and Cell Signaling

HACL1 (2-Hydroxy-acetyl-L-leucine), also known as 2-HPCL, is a protein that is expressed in various tissues throughout the body. It is a key regulator of the cytoskeleton, which is the structure that gives cells their shape and provides support.

HACL1 is a member of the HACL family, which includes several similar proteins that are involved in the regulation of cytoskeletal structure and stability. These proteins are known as HACL1-related proteins or HACL1-like proteins.

One of the unique features of HACL1 is its ability to interact with the cytoskeleton and regulate the formation of microtubules. Microtubules are the protein structures that give cells their structure and provide support, and they are important for a variety of cellular processes, including cell division, intracellular transport, and cell signaling.

HACL1 plays a key role in the regulation of microtubule formation by interacting with the protein tubulin. Tubulin is a protein that is derived from the cytoskeleton and is involved in the formation of microtubules. HACL1 interacts with tubulin to regulate the amount of tubulin that is available for the formation of microtubules.

In addition to its role in regulating microtubule formation, HACL1 is also involved in the regulation of cell signaling. It has been shown to play a role in a variety of signaling pathways, including the regulation of cell growth, differentiation, and survival.

HACL1 is also of interest as a potential drug target. Its role in the regulation of cytoskeletal structure and stability makes it a potential target for small molecules that can modulate its activity. Additionally, its involvement in various signaling pathways makes it a potential target for drugs that are currently being developed for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Overall, HACL1 is a protein that is of great interest due to its role in the regulation of cytoskeletal structure and stability. Its potential as a drug target makes it a promising target for the development of new therapies for a variety of diseases.

Protein Name: 2-hydroxyacyl-CoA Lyase 1

Functions: Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:28289220, PubMed:21708296, PubMed:10468558). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:28289220, PubMed:21708296, PubMed:10468558). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity)

The "HACL1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HACL1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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