HASPIN: A Protein Target for Small Molecules and Biomarkers (G83903)

Target Name: HASPIN

NCBI ID: G83903

HASPIN

HASPIN: A Protein Target for Small Molecules and Biomarkers

HASPIN (Serine/threonine-protein kinase haspin) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and skeletal muscles. It is a key regulator of cell signaling pathways, and its dysfunction has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, HASPIN has become a promising drug target and biomarker for a variety of diseases.

The HASPIN gene is located on chromosome 12 and encodes a protein that consists of 215 amino acid residues. The protein has a unique structure that includes a catalytic domain, a regulatory domain, and a variable region. The catalytic domain is responsible for the protein's catalytic activity, while the regulatory domain interacts with DNA to regulate gene expression. The variable region is responsible for the protein's ability to interact with other proteins and for its role in cell signaling pathways.

HASPIN functions as a key regulator of several signaling pathways that are involved in a variety of cellular processes, including cell growth, differentiation, and survival. One of the most well-studied signaling pathways that is regulated by HASPIN is the PI3K/Akt signaling pathway. This pathway is involved in the regulation of cell survival and growth, and is a key factor in the development and progression of many diseases, including cancer.

HASPIN is a critical regulator of the PI3K/Akt signaling pathway, and its dysfunction has been implicated in the development of many diseases. For example, HASPIN has been shown to play a role in the development and progression of cancer, including breast, ovarian, and colorectal cancers. HASPIN has also been shown to contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and to the development of autoimmune disorders, such as rheumatoid arthritis and type 1 diabetes.

In addition to its role in cell signaling pathways, HASPIN is also a potential drug target. The HASPIN gene has been shown to be involved in the regulation of cellular processes that are important for drug resistance, and it has been shown to interact with several drug targets, including the androgen receptor, the NF-kappa-B signaling pathway, and the TGF-β signaling pathway. These interactions make HASPIN an attractive target for small molecules that can modulate its function and the function of its downstream targets.

One of the challenges in studying HASPIN as a drug target is its complex structure and the difficulty of predicting how small molecules will interact with its various domains. However, research into the biology of HASPIN is ongoing, and several studies have identified potential small molecules that can modulate its function. For example, several studies have shown that HASPIN is involved in the regulation of cellular processes that are important for drug resistance, and that it can interact with several drug targets. These studies have identified a number of potential small molecules that can modulate HASPIN's function, including inhibitors of protein tyrosine kinases, inhibitors of the androgen receptor, and inhibitors of the TGF-β signaling pathway.

In addition to its potential as a drug target, HASPIN is also a valuable biomarker for the diagnosis and treatment of many diseases. Its functions as a regulator of cell signaling pathways are implicated in the development and progression of many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, HASPIN has been shown to be a promising biomarker for a variety of diseases, and it is being targeted by researchers as a potential drug target and diagnostic agent.

In conclusion, HASPIN is a protein that is involved in the regulation of cell signaling pathways and has been implicated in the development and progression of many diseases. Its dysfunction has

Protein Name: Histone H3 Associated Protein Kinase

Functions: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle

The "HASPIN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HASPIN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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