HAPSTR1: A Gene Encoding A Protein Implicated in Cellular Processes and Disease

Target Name: HAPSTR1

NCBI ID: G29035

HAPSTR1

HAPSTR1: A Gene Encoding A Protein Implicated in Cellular Processes and Disease

HAPSTR1 (Protein Object Name: HAPSTR1; Gene Name: GAA) is a gene that encodes a protein known as HAPSTR1. HAPSTR1 is a member of the HAPSTR family, which is characterized by the presence of a unique N-terminal domain called HAPSTR1-N. The HAPSTR1 gene is located on chromosome 16, specifically at position 7.2 kb upstream of the start codon.

HAPSTR1 is a 164 amino acid protein that is expressed in most tissues of the body. It is primarily localized to the endoplasmic reticulum (ER), where it is involved in the transport of various proteins to their final destinations. HAPSTR1 is also known to be involved in the regulation of cellular processes such as cell adhesion, migration, and survival.

One of the unique features of HAPSTR1 is its ability to interact with other proteins. HAPSTR1 can form a complex with the protein known as p120GAP, which is a known regulator of the PI3K/Akt signaling pathway. This interaction between HAPSTR1 and p120GAP is important for the regulation of various cellular processes, including cell signaling, cell growth, and cell survival.

Another feature of HAPSTR1 is its ability to interact with the protein known as CRLF1. CRLF1 is a protein that is known to be involved in the regulation of DNA binding and other cellular processes. This interaction between HAPSTR1 and CRLF1 is important for the regulation of various cellular processes, including cell signaling, gene expression, and DNA replication.

In addition to its role in the regulation of cellular processes, HAPSTR1 is also known to play a role in the development and progression of various diseases. For example, HAPSTR1 has been implicated in the development of cancer, specifically breast cancer. Studies have shown that HAPSTR1 is expressed in a variety of cancer cells and that it is involved in the regulation of various cellular processes that are associated with cancer progression.

Due to its involvement in the regulation of various cellular processes and its ability to interact with other proteins, HAPSTR1 is a potential drug target or biomarker. For example, drugs that can inhibit the interaction between HAPSTR1 and p120GAP or CRLF1 may be useful in the treatment of various diseases, including cancer. Additionally, drugs that can modulate the expression of HAPSTR1 may be useful in the treatment of various diseases, including genetic disorders.

In conclusion, HAPSTR1 is a gene that encodes a protein that is involved in the regulation of various cellular processes and has been implicated in the development and progression of various diseases. As a potential drug target or biomarker, HAPSTR1 is a promising target for the development of new therapies for a variety of diseases. Further research is needed to fully understand the role of HAPSTR1 in cellular processes and its potential as a drug target or biomarker.

Protein Name: HUWE1 Associated Protein Modifying Stress Responses

Functions: Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365)

The "HAPSTR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HAPSTR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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