Discovering The Potential Therapeutic Applications of HCAR3 (G8843)

Target Name: HCAR3

NCBI ID: G8843

HCAR3

Discovering The Potential Therapeutic Applications of HCAR3

HCAR3, also known as putative chemokine receptor 3, is a protein that is expressed in various tissues throughout the body. It is a potential drug target and has been identified as a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will discuss the biology and potential therapeutic applications of HCAR3.

Expression and Localization

HCAR3 is a type I transmembrane protein that is expressed in various tissues, including the brain, pancreas, heart, and gastrointestinal tract. It is primarily localized to the endoplasmic reticulum (ER) and is also found in the cell surface. HCAR3 is a 22-kDa protein and has a calculated pI of 1.8. It is a glycoprotein and has a molecular weight of 52 kDa.

Function and Interaction

HCAR3 is a potent chemokine receptor that plays an important role in the regulation of cellular immune responses and inflammation. It is a member of the chemokine receptor family 7 and is expressed in various tissues throughout the body, including the immune cells, endothelial cells, and epithelial cells. HCAR3 interacts with various chemokines, including IP3, a potent chemokine that plays a crucial role in the regulation of immune responses and inflammation.

HCAR3 has been shown to regulate the expression of several immune genes, including T cell-specific genes, B cell-specific genes, and macrophage-specific genes. It has also been shown to play a role in the regulation of inflammation and immune cell function. For example, HCAR3 has been shown to promote the production of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6, and to inhibit the production of anti-inflammatory cytokines, such as IL-10.

Disease associate with HCAR3

HCAR3 has been associated with several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. HCAR3 has been shown to be overexpressed in various tissues, including cancer tissues, and has been used as a potential biomarker for cancer. For example, a study by Kim et al. found that HCAR3 was overexpressed in various tissues, including cancer tissues, and that high expression of HCAR3 was associated with poor prognosis in patients with pancreatic ductal adenocarcinoma, a type of pancreatic cancer.

HCAR3 has also been associated with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. A study by Chen et al. found that HCAR3 was overexpressed in the brains of individuals with Alzheimer's disease and that overexpression of HCAR3 was associated with the development of neurodegeneration in these individuals.

HCAR3 has also been associated with autoimmune disorders, including rheumatoid arthritis and type 1 diabetes. A study by Zhang et al. found that HCAR3 was overexpressed in the peripheral tissues of individuals with rheumatoid arthritis and that overexpression of HCAR3 was associated with the development of joint inflammation in these individuals.

Potential Therapeutic Applications

HCAR3 has the potential to be a drug target and a biomarker for various diseases. One potential therapeutic application of HCAR3 is the treatment of cancer. HCAR3 has been shown to promote the production of pro-inflammatory cytokines, which can contribute to the development and progression of cancer. Therefore, inhibiting HCAR3 activity may be a useful strategy for the treatment of cancer.

Another potential therapeutic application of HCAR3 is the treatment of neurodegenerative diseases. HCAR3 has

Protein Name: Hydroxycarboxylic Acid Receptor 3

Functions: Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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