SPAG8: Phospholipid Interaction and Cell Signaling (G26206)

Target Name: SPAG8

NCBI ID: G26206

SPAG8

SPAG8: Phospholipid Interaction and Cell Signaling

SPAG8 (Small phosphatidylserine binding protein 8) is a protein that is expressed in various tissues throughout the body. It is a member of the SPG family of proteins, which are known for their ability to interact with phosphatidylserine (PS) on various cell surfaces. PS is a type of phospholipid that is derived from the hydrophobic tail of an lipid molecule. It is involved in various cellular processes, including cell signaling, inflammation, and stress resistance.

SPAG8 is a 21-kDa protein that is expressed in a variety of tissues, including muscle, heart, brain, and kidney. It is primarily localized to the cytoplasm of cells, where it can interact with PS. SPAG8 has been shown to play a role in various cellular processes, including the regulation of cell signaling pathways, the development of cancer, and the response to stress.

One of the key functions of SPAG8 is its ability to interact with PS. PS is a phospholipid that is derived from the hydrophobic tail of an lipid molecule. It is known for its ability to interact with a wide variety of proteins, including SPAG8 . These interactions can modulate the structure and function of SPAG8 and other proteins.

SPAG8 can interact with PS through several different mechanisms. One of the most well-studied mechanisms involves the formation of SPAG8-PS domains. These domains can be formed by the interaction of SPAG8 with PS. The interaction between SPAG8 and PS is strengthened by the presence of certain amino acids, such as Asp and Glu. These amino acids can form a stable complex with PS, which can then interact with SPAG8.

SPAG8 can also interact with PS through the formation of SPAG8-PS-ASP. These domains can be formed by the interaction of SPAG8 with PS and Asp. The interaction between SPAG8 and PS is strengthened by the presence of these amino acids, which can form a stable complex with PS.

SPAG8 has been shown to play a role in the regulation of cell signaling pathways. For example, SPAG8 has been shown to interact with the protein kinase kinase (PKP) 纬, which is involved in the regulation of cell signaling pathways. These interactions can modulate the structure and function of SPAG8 and PKP 纬.

SPAG8 has also been shown to be involved in the development of cancer. For example, SPAG8 has been shown to be involved in the regulation of the cell cycle, which is a critical process for the development of cancer. These interactions can modulate the structure and function of SPAG8, which can then contribute to the development of cancer.

SPAG8 has also been shown to play a role in the response to stress. For example, SPAG8 has been shown to interact with the protein heat shock protein (Hsp) 70, which is involved in the regulation of stress responses. These interactions can modulate the structure and function of SPAG8 and Hsp70, which can then contribute to the response to stress.

In conclusion, SPAG8 is a protein that is involved in various cellular processes. It can interact with PS, which is a phospholipid that is derived from the hydrophobic tail of an lipid molecule. These interactions can modulate the structure and function of SPAG8 and other proteins. SPAG8 has been shown to play a role in the regulation of cell signaling pathways, the development of cancer, and the response to stress. Therefore, SPAG8 may be a drug target or biomarker for various diseases.

Protein Name: Sperm Associated Antigen 8

Functions: Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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