Target Name: TIMM8A
NCBI ID: G1678
Review Report on TIMM8A Target / Biomarker Content of Review Report on TIMM8A Target / Biomarker
TIMM8A
Other Name(s): TIM8 | Translocase of inner mitochondrial membrane 8A, transcript variant 1 | deafness dystonia protein 1 | Mitochondrial import inner membrane translocase subunit Tim8 A (isoform 1) | deafness/dystonia peptide | TIMM8A variant 1 | Deafness/dystonia peptide | Deafness dystonia protein 1 | Mitochondrial import inner membrane translocase subunit Tim8 A | DFN1 | translocase of inner mitochondrial membrane 8 homolog A | DDP1 | DDP | Translocase of inner mitochondrial membrane 8 homolog A | MGC12262 | TIM8A_HUMAN | translocase of inner mitochondrial membrane 8A | X-linked deafness dystonia protein | OTTHUMP00000023681 | MTS

TIMM8A: A Potential Drug Target and Biomarker

Timm8a, a gene that encodes a protein known as Timm8, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for researchers to investigate, and potentially, develop new treatments.

The protein encoded by the TIMM8A gene is a highly conserved protein that is found in various cell types throughout the body. It is characterized by a distinct N-terminus, a transmembrane region, and a C-terminus that contains a unique farnesylated cysteine residue. This cysteine residue is known to play a crucial role in the regulation of cellular processes, including protein stability, localization, and interactions with other cellular components.

One of the most significant features of TIMM8A is its ability to interact with various drug molecules, including small molecules, peptides, and proteins. This interactivity makes it an attractive target for drug development, as it allows for the development of compounds that can specifically target TIMM8A and modulate its function to achieve desired therapeutic effects.

In addition to its potential as a drug target, TIMM8A has also been identified as a potential biomarker for various diseases. Its expression has been observed in a variety of tissues and fluids, including blood, saliva, urine, and brain, which suggests its potential as a biomarker for a range of diseases. Furthermore, its expression has been implicated in the development and progression of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

The unique structure and function of TIMM8A have also made it an attractive target for study of its underlying molecular mechanisms. The conserved N-terminus and transmembrane region suggest that it plays a critical role in the regulation of cellular processes, while the cysteine residue and its ability to interact with other cellular components suggest that it is involved in protein stability and localization.

In conclusion, TIMM8A is a protein that has the potential to be a drug target and biomarker for a variety of diseases. Its unique structure and function, as well as its ability to interact with various drug molecules and serve as a biomarker, make it an attractive target for research and development of new treatments. Further studies are needed to fully understand its role in the regulation of cellular processes and its potential as a drug and biomarker.

Protein Name: Translocase Of Inner Mitochondrial Membrane 8A

Functions: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development

The "TIMM8A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TIMM8A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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TIMM8AP1 | TIMM8B | TIMM9 | TIMMDC1 | TIMP1 | TIMP2 | TIMP3 | TIMP4 | TINAG | TINAGL1 | TINCR | TINF2 | TIPARP | TIPARP-AS1 | TIPIN | TIPRL | TIRAP | TIRAP-AS1 | TJAP1 | TJP1 | TJP2 | TJP3 | TK1 | TK2 | TKFC | TKT | TKTL1 | TKTL2 | TLCD1 | TLCD2 | TLCD3A | TLCD3B | TLCD4 | TLCD4-RWDD3 | TLCD5 | TLDC2 | TLE1 | TLE1-DT | TLE2 | TLE3 | TLE4 | TLE5 | TLE6 | TLK1 | TLK2 | TLL1 | TLL2 | TLN1 | TLN2 | TLNRD1 | TLR1 | TLR10 | TLR12P | TLR2 | TLR3 | TLR4 | TLR5 | TLR6 | TLR7 | TLR8 | TLR8-AS1 | TLR9 | TLX1 | TLX1NB | TLX2 | TLX3 | TM2D1 | TM2D2 | TM2D3 | TM4SF1 | TM4SF1-AS1 | TM4SF18 | TM4SF19 | TM4SF19-AS1 | TM4SF19-DYNLT2B | TM4SF20 | TM4SF4 | TM4SF5 | TM6SF1 | TM6SF2 | TM7SF2 | TM7SF3 | TM9SF1 | TM9SF2 | TM9SF3 | TM9SF4 | TMA16 | TMA7 | TMBIM1 | TMBIM4 | TMBIM6 | TMC1 | TMC2 | TMC3 | TMC4 | TMC5 | TMC6 | TMC7 | TMC8 | TMCC1