Target Name: TIPIN
NCBI ID: G54962
Review Report on TIPIN Target / Biomarker Content of Review Report on TIPIN Target / Biomarker
TIPIN
Other Name(s): TIMELESS-interacting protein isoform X1 | TIMELESS-interacting protein, transcript variant X1 | TIPIN_HUMAN | TIMELESS-interacting protein | TIMELESS interacting protein | CSM3 homolog | TIPIN variant X1

TIPIN: A Potential Drug Target and Biomarker for the Treatment of Alzheimer's Disease

Alzheimer's disease is a neurodegenerative disorder that affects millions of people worldwide, primarily in old age. It is characterized by progressive memory loss, decline in cognitive abilities, and a growing risk of dementia. The most common cause of Alzheimer's disease is the accumulation of beta-amyloid plaques, which are thought to cause the neurodegeneration that occurs in the disease. However, the exact mechanisms underlying the development and progression of Alzheimer's disease remain largely unexplored.

Recent studies have identified several potential drug targets and biomarkers for the treatment of Alzheimer's disease. One of these targets is TIPIN (TIMELESS-interacting protein isoform X1), a protein that has been shown to interact with beta-amyloid plaques and may play a role in the development of the disease. In this article, we will discuss the potential implications of TIPIN as a drug target and biomarker for the treatment of Alzheimer's disease.

The Role of TIPIN in Alzheimer's Disease

TIPIN is a protein that is expressed in various tissues throughout the body, including the brain. It is a member of the TIM family of proteins, which are known for their role in regulating protein interactions and signaling pathways. TIPIN has been shown to interact with several proteins, including beta-amyloid plaques.

尾-Amyloid plaques are one of the hallmark hallmarks of Alzheimer's disease, and are thought to play a key role in the neurodegeneration that occurs in the disease. They are composed of abnormally aggregated beta-amyloid peptides, which can interact with various proteins and contribute to the formation of neurofibrillary tangles and other hallmarks of the disease. TIPIN has been shown to interact with beta-amyloid peptides and may help to regulate their aggregation.

In addition to its potential role in regulating beta-amyloid peptides, TIPIN has also been shown to interact with several other proteins that are involved in the development and progression of Alzheimer's disease. For example, TIPIN has been shown to interact with the protein TAT (Tau-associated protein), which is known to be involved in the regulation of microtubules and is thought to contribute to the neurodegeneration that occurs in the disease. TIPIN has also been shown to interact with the protein SENP1 (Spermin-associated protein 1), which is involved in the regulation of DNA damage repair and may play a role in the regulation of the immune response.

The Potential Implications of TIPIN as a Drug Target

The accumulation of beta-amyloid plaques is thought to be a key driver of the development and progression of Alzheimer's disease. By interacting with beta-amyloid peptides and other proteins involved in the regulation of the disease, TIPIN may have a role in the regulation of beta-amyloid plaque formation and may be a potential drug target for the treatment of Alzheimer's disease.

One potential approach to targeting TIPIN as a drug target is the use of small molecules that can modulate its activity. For example, drugs that can inhibit the interaction of TIPIN with beta-amyloid peptides or other proteins involved in the regulation of the disease may be effective in reducing the formation of beta-amyloid plaques and may be a potential treatment for Alzheimer's disease.

In addition to its potential use as a drug target, TIPIN may also be used as a biomarker for the diagnosis and monitoring of Alzheimer's disease. The accumulation of beta-amyloid plaques is a key hallmark of the disease, and may be a useful diagnostic marker for

Protein Name: TIMELESS Interacting Protein

Functions: Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:23359676, PubMed:35585232, PubMed:17102137). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:23359676, PubMed:35585232, PubMed:17102137, PubMed:17116885, PubMed:17296725)

The "TIPIN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TIPIN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

TIPRL | TIRAP | TIRAP-AS1 | TJAP1 | TJP1 | TJP2 | TJP3 | TK1 | TK2 | TKFC | TKT | TKTL1 | TKTL2 | TLCD1 | TLCD2 | TLCD3A | TLCD3B | TLCD4 | TLCD4-RWDD3 | TLCD5 | TLDC2 | TLE1 | TLE1-DT | TLE2 | TLE3 | TLE4 | TLE5 | TLE6 | TLK1 | TLK2 | TLL1 | TLL2 | TLN1 | TLN2 | TLNRD1 | TLR1 | TLR10 | TLR12P | TLR2 | TLR3 | TLR4 | TLR5 | TLR6 | TLR7 | TLR8 | TLR8-AS1 | TLR9 | TLX1 | TLX1NB | TLX2 | TLX3 | TM2D1 | TM2D2 | TM2D3 | TM4SF1 | TM4SF1-AS1 | TM4SF18 | TM4SF19 | TM4SF19-AS1 | TM4SF19-DYNLT2B | TM4SF20 | TM4SF4 | TM4SF5 | TM6SF1 | TM6SF2 | TM7SF2 | TM7SF3 | TM9SF1 | TM9SF2 | TM9SF3 | TM9SF4 | TMA16 | TMA7 | TMBIM1 | TMBIM4 | TMBIM6 | TMC1 | TMC2 | TMC3 | TMC4 | TMC5 | TMC6 | TMC7 | TMC8 | TMCC1 | TMCC1-DT | TMCC2 | TMCC3 | TMCO1 | TMCO1-AS1 | TMCO2 | TMCO3 | TMCO4 | TMCO5A | TMCO5B | TMCO6 | TMED1 | TMED10 | TMED10P1 | TMED11P