Rhod: A Versatile Drug Target for GPCR-mediated Signaling (G29984)

Target Name: RHOD

NCBI ID: G29984

RHOD

Rhod: A Versatile Drug Target for GPCR-mediated Signaling

Rhod (RHOM) is a protein that is expressed in various tissues throughout the body. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a key role in cellular signaling . Rhod is involved in a wide range of physiological processes in the body, including sensory perception, neurotransmission, and hormone signaling.

One of the unique features of Rhod is its ability to interact with a variety of different GPCRs. This is accomplished through its extracellular domain, which consists of a long coiled-coil that can interact with GPCRs in a process known as GPCR-mediated signaling. This allows Rhod to act as a versatile drug target, as it can be targeted by a variety of different GPCRs with different half-lives and affinity.

Rhod is also involved in the regulation of ion channels in cells. In particular, it is known to play a role in the regulation of the sodium (Na+) channels, which are involved in the rapid transport of electrical signals through the cell membrane. This is important for a wide range of physiological processes, including muscle contractions and neural signaling.

In addition to its role in cellular signaling, Rhod is also thought to have a number of potential therapeutic applications. For example, it is involved in the regulation of pain perception, which is important for the treatment of chronic pain conditions such as cancer and neuroinflammatory diseases. It is also involved in the regulation of neurotransmission, which is important for the treatment of mood disorders and neurological disorders.

GPCR-mediated signaling is a highly conserved process that is involved in the regulation of many different physiological processes in the body. It is therefore an attractive target for drug development, as it allows for the development of small molecules that can modulate the activity of GPCRs.

In conclusion, Rhod is a protein that is involved in a wide range of physiological processes in the body. Its ability to interact with a variety of different GPCRs makes it an attractive drug target, and its role in the regulation of cellular signaling and ion channels makes it a valuable tool for the development of new therapeutic agents. Further research is needed to fully understand the function of Rhod and its potential therapeutic applications.

Protein Name: Ras Homolog Family Member D

Functions: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution

The "RHOD Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RHOD comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets