An Overview of RIF1: A Promising Drug Target and Biomarker (G55183)

Target Name: RIF1

NCBI ID: G55183

RIF1

An Overview of RIF1: A Promising Drug Target and Biomarker

The research in the field of RNA interference (RNAi) has been continuously gaining momentum over the past decade, and RIF1 (RIF1_HUMAN) has emerged as a promising drug target and biomarker. RIF1 is a small non-coding RNA molecule that plays a crucial role in post-transcriptional gene regulation, specifically in the regulation of RNA translation efficiency. In this article, we will provide an overview of RIF1, its functions, and potential as a drug target and biomarker.

Structure and Function

RIF1 is a non-coding RNA molecule that contains 198 amino acid residues. It belongs to the HTRN (helices, tranions, and non-coding regions) family and is characterized by a unique open-loop structure that includes a 5' region that is involved in the formation of a stem-loop and a 3' region that is involved in the formation of a loop.

RIF1 functions as a negative regulator of gene expression by binding to specific mRNAs and preventing their translation into proteins. This process is known as post-transcriptional repression and is a well-established mechanism for regulating gene expression in various organisms, including humans.

RIF1 has been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis, and translation efficiency. For example, studies have shown that RIF1 can inhibit the translation of certain mRNAs, such as those encoding proteins involved in cell growth and differentiation, leading to increased cell proliferation and survival.

In addition to its role in post-transcriptional repression, RIF1 has also been shown to play a role in the regulation of protein stability and interactions. This is because RIF1 is involved in the formation of a stem-loop, which can interact with other non-coding RNAs and proteins to regulate their stability and interactions.

Potential as a Drug Target

The potential of RIF1 as a drug target is due to its unique mechanism of action and its involvement in various cellular processes. One of the main advantages of RIF1 as a drug target is its high specificity, as studies have shown that RIF1 can effectively inhibit the translation of specific mRNAs. This makes it a promising target for small molecule inhibitors that can be used to treat various diseases.

Another advantage of RIF1 as a drug target is its involvement in the regulation of cellular processes that are often disrupted in diseases, such as cancer, neurodegenerative diseases, and autoimmune diseases. For example, RIF1 has been shown to play a role in the regulation of apoptosis, which is a critical process that helps eliminate damaged or dysfunctional cells.

In addition to its potential as a drug target, RIF1 has also been shown to be a potential biomarker for various diseases. For example, studies have shown that RIF1 levels are often decreased in various diseases, such as cancer, neurodegenerative diseases, and autoimmune diseases. This suggests that RIF1 may be a useful biomarker for these diseases and can be used to monitor disease progression and the effectiveness of treatments.

Current Approaches to Target RIF1

Currently, there are several approaches being used to target RIF1, including small molecule inhibitors, RNA interference knockdowns, and CRISPR/Cas9-mediated gene editing.

Small molecule inhibitors are one of the most promising approaches to targeting RIF1. These inhibitors can be designed to specifically bind to RIF1 and prevent it from binding to mRNAs. One of the most promising small molecule inhibitors is JNJ-7626, which is a compound that was shown to inhibit the

Protein Name: Replication Timing Regulatory Factor 1

Functions: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity)

The "RIF1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RIF1 comprehensively, including but not limited to:
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•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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