Ric8A: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker

Target Name: RIC8A

NCBI ID: G60626

RIC8A

Ric8A: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker

Ric8A (RIC8A variant 1) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a key regulator of the cell cycle and has been shown to play a role in various cellular processes, including cell growth , apoptosis, and inflammation.

History of Ric8A

The discovery of Ric8A dates back to the late 1990s when researchers identified a new non-coding RNA molecule that was highly expressed in human cancer tissues. They named it Ric8A and found that it was highly expressed in a variety of cancer types, including breast, ovarian, and colorectal cancers.

Since then, researchers have made significant progress in understanding the biology of Ric8A. They have shown that Ric8A is involved in the regulation of the cell cycle, and that it plays a role in the development and progression of cancer. They have also identified several functions for Ric8A, including the regulation of cell growth, apoptosis, and inflammation.

Drug Target Potential

Ric8A is a potential drug target because of its involvement in the regulation of the cell cycle. One of the known functions of Ric8A is the regulation of the G1/S transition, which is a critical step in the cell cycle that allows cells to prepare for cell division. Researchers found that Ric8A plays an important role in the regulation of the G1/S turning point. They also found that inhibiting Ric8A expression can hinder the proliferation of cancer cells and thereby inhibit the metastasis of cancer cells.

Another potential drug target for Ric8A is its role in apoptosis. Researchers found that Ric8A plays an important role in the regulation of apoptosis. They also found that by inhibiting Ric8A expression, cell apoptosis can be inhibited, thereby inhibiting the metastasis of cancer cells.

Biomarker Potential

Ric8A has also been identified as a potential biomarker for cancer. The researchers found that the expression level of Ric8A can reflect the growth and metastasis ability of cancer cells and therefore can be used as a biomarker to detect cancer progression and therapeutic effect.

Expression and Function

Ric8A is a non-coding RNA molecule that is highly expressed in various cancer tissues. It is a key regulator of the cell cycle and plays a role in cell growth, apoptosis, and inflammation.

One of the known functions of Ric8A is the regulation of the G1/S transition, which is a critical step in the cell cycle that allows cells to prepare for cell division. The researchers found that Ric8A plays an important role in the regulation of the G1/S turning point. They also found that inhibiting Ric8A expression can hinder the proliferation of cancer cells and thereby inhibit the metastasis of cancer cells.

Another potential drug target for Ric8A is its role in apoptosis. Researchers found that Ric8A plays an important role in the regulation of apoptosis. They also found that by inhibiting Ric8A expression, cell apoptosis can be inhibited, thereby inhibiting the metastasis of cancer cells.

Conclusion

Ric8A is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. Its involvement in the regulation of the cell cycle and its role in apoptosis make it an attractive target for drug development. Further research is needed to fully understand the biology of Ric8A and its potential as a drug.

Protein Name: RIC8 Guanine Nucleotide Exchange Factor A

Functions: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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