Riox1: A Potential Drug Target and Biomarker (G79697)

Target Name: RIOX1

NCBI ID: G79697

RIOX1

Riox1: A Potential Drug Target and Biomarker

Riox1 (FLJ21802) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and pancreas. It is a member of the superfamily of F-actinin-like proteins, which are a group of transmembrane proteins that are characterized by the presence of an F-actinin-like domain and various non-overlapping domains, such as an extracellular domain, a transmembrane domain, and an intracellular domain.

The function of Riox1 is not well understood, but it is thought to play a role in various physiological processes in the body. Several studies have suggested that Riox1 may be involved in the regulation of cell adhesion, migration, and signaling.

Drug Targeting

Drug targeting is a process that involves the use of small molecules or antibodies to selectively bind to a specific protein and alter its function. This process is used to treat various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Riox1 is a potential drug target because of its unique structure and the various functions that have been proposed to be involved in its activity. Several studies have suggested that Riox1 may be a useful target for small molecule inhibitors or antibodies that can modulate its activity.

One potential mechanism by which Riox1 may be targeted is through its role in cell adhesion. Riox1 is a protein that is involved in the formation of tight junctions, which are specialized junctions that are responsible for maintaining tissue structure and preventing the movement of harmful substances into the body.

Several studies have suggested that Riox1 plays a role in the regulation of cell adhesion by interacting with the protein cadherin. cadherin is a transmembrane protein that is involved in cell-cell adhesion, and it is thought to be regulated by Riox1.

Another potential mechanism by which Riox1 may be targeted is through its role in cell signaling. Riox1 is a protein that is involved in the regulation of various signaling pathways, including the TGF-β pathway. TGF-β is a signaling pathway that is involved in the regulation of cell growth, differentiation, and survival, and it is thought to be regulated by Riox1.

In addition to its role in cell signaling, Riox1 is also thought to be involved in the regulation of cell adhesion and migration. Several studies have suggested that Riox1 plays a role in the regulation of cell migration by interacting with the protein vimentin. vimentin is a transmembrane protein that is involved in the regulation of cell shape and is thought to be regulated by Riox1.

Biomarker

Riox1 is also considered as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because its expression is known to be affected by various diseases and may be used as a diagnostic or therapeutic target.

For example, some studies have suggested that decreased Riox1 expression may be associated with poor prognosis in patients with pancreatic ductal adenocarcinoma, a type of cancer that arises from the ducts that carry digestive enzymes from the pancreas to the small intestine.

Additionally, Riox1 has also been suggested as a potential therapeutic target for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Studies have shown that Riox1 is involved in the regulation of neurodegenerate diseases and that its expression is affected by various neurodegenerate diseases.

Conclusion

Riox1 is a protein that is expressed in various tissues of the body and is thought to play a role in various physiological processes in the body. Its unique structure and the various functions that have been proposed to be involved in its activity make it a potential drug target and a useful biomarker for various diseases. Further studies are needed to fully understand the role of Riox1 in the regulation of various physiological processes and to develop effective therapies based on

Protein Name: Ribosomal Oxygenase 1

Functions: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053)

The "RIOX1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RIOX1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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